YKL-40 is a local marker for inflammation in patients with pseudoexfoliation syndrome
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Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nature Publishing Group
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: To investigate the YKL-40, as a marker of inflammation, in aqueous humor and serum of cataract patients with and without pseudoexfoliation syndrome (PEX). Methods: Aqueous humor and serum samples were obtained from 44 patients who underwent phacoemulsification surgery. All patients were divided into two groups: PEX (n = 24) and control (n = 20). YKL-40 levels were measured with enzyme-linked immunosorbent assay (ELISA). The differences between the groups were assessed by using Chi-square and independent sample t-tests. The Pearson correlation coefficient was used to evaluate the correlation between variables. Results: There was a significant difference between the mean YKL-40 levels in the aqueous humor of PEX group (112.0 ± 35.8 ng/mL) and control subjects (88.2 ± 30.6 ng/mL) (P = 0.025). However, the difference between the mean YKL-40 levels in the serum of PEX group (53.5 ± 29.1 ng/mL) and control subjects (44.6 ± 30.2 ng/mL) was non-significant (P = 0.326). The correlation between aqueous humor and serum YKL-40 concentrations was significant in both the groups (r = 0.833, P < 0.001; r = 0.840, P < 0.001, respectively). Conclusions: Increased aqueous humor levels of YKL-40 demonstrate that it is local, but not a systemic marker for inflammation in patients with PEX. © 2018, The Royal College of Ophthalmologists.
Açıklama
Anahtar Kelimeler
biological marker, chitinase 3 like protein 1, tropicamide, biological marker, CHI3L1 protein, human, chitinase 3 like protein 1, growth promotor, aged, anterior lens capsule, aqueous humor, Article, blood sampling, case control study, cataract, clinical article, college, controlled study, correlation coefficient, enzyme linked immunosorbent assay, eye examination, female, gonioscopy, human, inflammation, intraocular pressure, laboratory test, male, ophthalmoscopy, phacoemulsification, prospective study, protein blood level, pseudoexfoliation, senile cataract, serum, slit lamp microscopy, tonometry, blood, inflammation, metabolism, pseudoexfoliation, very elderly, Aged, Aged, 80 and over, Aqueous Humor, Biomarkers, Case-Control Studies, Cataract, Chitinase-3-Like Protein 1, Enzyme-Linked Immunosorbent Assay, Exfoliation Syndrome, Female, Growth Substances, Humans, Inflammation, Male, Phacoemulsification, Prospective Studies
Kaynak
Eye (Basingstoke)
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
33
Sayı
5
