Beneficial effects of melatonin and BQ-123 on the rat testis damage caused by cigarette smoke

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dc.authorid0000-0003-2465-5389
dc.authorid0000-0001-8013-3302
dc.authorscopusid8502405200
dc.authorscopusid49461500100
dc.authorscopusid50161770200
dc.authorscopusid6603109651
dc.authorscopusid14044238300
dc.authorscopusid23988674500
dc.authorscopusid7006831777
dc.authorwosidCayli, Sevil/V-2342-2019
dc.contributor.authorAslan, Hüseyin
dc.contributor.authorKesici, Hakan
dc.contributor.authorKaraca, Zafer İsmail
dc.contributor.authorÖzyurt, Birsen
dc.contributor.authorTaş, Ufuk
dc.contributor.authorEkici, Fatih
dc.contributor.authorÇaylı, Sevil
dc.contributor.authorErdoğan, Hasan
dc.date.accessioned2022-05-11T14:41:23Z
dc.date.available2022-05-11T14:41:23Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractBackground/aim: Several studies have demonstrated that cigarette smoke has detrimental effects on testicular function. However, it is unknown whether melatonin or BQ-123 has beneficial effects on the rat testis damage caused by cigarette smoke. The aim of the present study was to investigate the beneficial effects of melatonin or BQ-123 on the testicular damage caused by cigarette smoke. Materials and methods: Twenty Wistar rats were randomly divided into 4 equal groups: control group (n = 5), cigarette smoke group (n = 5), melatonin group (n = 5), and BQ-123 group (n = 5). At the end of 4 weeks, all the rats were sacrificed for histopathological evaluation and subsequent stereological analysis. The optical fractionator counting method, the most efficient and unbiased method, was used to estimate the total number of spermatogonia and spermatocytes. Results: All the control testes demonstrated complete spermatogenesis. There was a significant decrease in the germ cells of rats exposed to cigarette smoke for 4 weeks. After the application of melatonin or BQ-123, the total number of spermatogonia and spermatocytes in the testes was significantly higher. Conclusion: Based on these findings, melatonin and BQ-123 are able to minimize the degenerative effects of cigarette smoke by increasing the germ cell count.
dc.description.sponsorshipGaziosmanpasa University Research FundGaziosmanpasa University [2006/19]
dc.description.sponsorshipThis study was supported by Gaziosmanpasa University Research Fund Project no. 2006/19. We thank Dr Bahadir Ungor (rest in peace) for all his assistance.
dc.identifier.doi10.3906/sag-1312-66
dc.identifier.endpage17
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.pmid25790524
dc.identifier.scopus2-s2.0-84920019804
dc.identifier.scopusqualityQ3
dc.identifier.startpage11
dc.identifier.urihttps://doi.org/10.3906/sag-1312-66
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9165
dc.identifier.volume45
dc.identifier.wosWOS:000347840000003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErdoğan, Hasan
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCigarette smoke
dc.subjectrat
dc.subjecttestis
dc.subjectstereology
dc.subjectmelatonin
dc.subjectBQ-123
dc.subjectTesticular Function
dc.subjectSex-Hormones
dc.subjectPlasma
dc.subjectProtection
dc.subjectToxicity
dc.subjectCell
dc.titleBeneficial effects of melatonin and BQ-123 on the rat testis damage caused by cigarette smoke
dc.typeArticle

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