Comparison of the prophylactic use of ibandronate and its use in early-stage osteonecrosis in rats with steroid-induced osteonecrosis of the femoral head

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dc.authoridCATALTEPE, AZIZ/0000-0001-9785-9062
dc.authoridCAGLAR, Aysel/0000-0002-3556-2527
dc.authoridDincel, Yasar Mahsut/0000-0001-6576-1802
dc.contributor.authorCaglar, Sever
dc.contributor.authorDasnci, Mustafa Fatih
dc.contributor.authorAcar, Abdurrahman
dc.contributor.authorCaglar, Aysel
dc.contributor.authorDincel, Yasar Mahsut
dc.contributor.authorCataltepe, Aziz
dc.date.accessioned2024-10-29T17:59:46Z
dc.date.available2024-10-29T17:59:46Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjectives: The aim of this study was to investigate the effects of ibandronate before and after the onset of osteonecrosis in rats with steroid-induced osteonecrosis of the femoral head.Materials and methods: A total of 24 female Sprague-Dawley rats were used in this study. Three groups were formed with eight rats in each group. The first group was the prophylactic group that received ibandronate treatment before and after the onset of osteonecrosis (Group PT). The second group received ibandronate treatment three weeks after the development of osteonecrosis (Group TAO). The third group was the control group in which osteonecrosis was created, but only normal saline (NS) was given. At the end of the study, all rats were sacrificed, and their right femoral heads were removed, fixed with formalin, and sent for micro-computed tomography. Hematoxylin-eosin (H & E) and immunohistochemical examinations of the right femoral head sections were performed.Results: In the PT group, the trabecular thickness was significantly higher compared to those of the TAO and control groups (p<0.05). The trabecular thickness did not significantly differ between the TAO and control groups. The trabecular bone pattern factor was significantly higher in the PT group compared to the control and TAO groups (p<0.05); however, it showed no significant difference between the TAO and control groups. The incidence of type 2 osteonecrosis in the PT and TAO groups was significantly lower than that in the control group (p<0.05). The incidence of tissue-non-specific alkaline phosphatase (TNAPase) immunoreactivity of osteoblast positivity was significantly higher in the PT and TAO groups compared to the control group (p<0.05), whereas the incidence of TRAPase immunoreactivity of osteoclastic positivity was significantly lower in the PT and TAO groups compared to the control group (p<0.05).Conclusion: Intravenous administration of ibandronate before the onset of the disease was more effective in the treatment of osteonecrosis in rats with steroid-induced osteonecrosis of the femoral head.
dc.identifier.doi10.52312/jdrs.2023.1096
dc.identifier.endpage650
dc.identifier.issn2687-4792
dc.identifier.issue3en_US
dc.identifier.pmid37750269
dc.identifier.scopus2-s2.0-85173181296
dc.identifier.scopusqualityQ2
dc.identifier.startpage640
dc.identifier.trdizinid#BAŞV!
dc.identifier.urihttps://doi.org/10.52312/jdrs.2023.1096
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1227265
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14831
dc.identifier.volume34
dc.identifier.wosWOS:001055522700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Joint Diseases Foundation
dc.relation.ispartofJoint Diseases and Related Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBisphosphonate
dc.subjectfemoral head
dc.subjectibandronate
dc.subjectosteonecrosis
dc.subjectrat
dc.titleComparison of the prophylactic use of ibandronate and its use in early-stage osteonecrosis in rats with steroid-induced osteonecrosis of the femoral head
dc.title.alternativeComparison of the prophylactic use of ibandronate and its use in early-stage osteonecrosis in rats with steroid-induced osteonecrosis of the femoral head
dc.typeArticle

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