Synthesis, structural characterization and cytostatic properties of N,N-dicyclohexyldithiooxamide complexes of antimony(III) halides (SbX3, X: Br or I)

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dc.authorid0000-0001-9556-6266
dc.authorid0000-0003-3264-2406
dc.authorid0000-0003-3164-0038
dc.authorid0000-0003-0377-2260
dc.authorid0000-0003-1188-6233
dc.authorid0000-0001-7202-9169
dc.authorid0000-0001-6727-2711
dc.authorscopusid36785856200
dc.authorscopusid55227384500
dc.authorscopusid46860923200
dc.authorscopusid6507202525
dc.authorscopusid57209326301
dc.authorscopusid7005646655
dc.authorscopusid6602925165
dc.authorwosidHadjikakou, Sotiris K./I-2909-2019
dc.authorwosidürgüt, ozan suleyman/ABA-5795-2020
dc.authorwosidOzturk, Ibrahim Ismet/K-1352-2013
dc.authorwosidKourkoumelis, Nikolaos/B-8555-2009
dc.authorwosidGrze?kiewicz, Anita/E-1315-2018
dc.contributor.authorÖztürk, İbrahim İsmet
dc.contributor.authorÜrgüt, O.
dc.contributor.authorBanti, Christina N.
dc.contributor.authorKourkoumelis, Nikolaos
dc.contributor.authorOwczarzak, A. M.
dc.contributor.authorKubicki, M.
dc.contributor.authorHadjikakou, Sotiris K.
dc.date.accessioned2022-05-11T14:29:57Z
dc.date.available2022-05-11T14:29:57Z
dc.date.issued2014
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractThe novel antimony(III) halide complexes with the bi-dentate substituted dithiooxamide ligand, N,N-dicyclohexyldithiooxamide (HDTOA) of formulae {[SbBr3(HDTOA)(1.5)]}(n) (I) and ([SbI3(HDTOA)(1.5)]center dot C6H6}(n) (2), were prepared by reacting antimony(III) bromide or antimony(III) iodide with HDTOA in 1:1 molar ratio. The compounds were characterized by their m.p., FT-IR spectroscopy, Raman spectroscopy, H-1, C-13 NMR spectroscopy, Thermal Gravi metric - Differential Thermal Analysis (TG-DTA) and single crystal X-ray diffraction analysis. Both complexes are polymeric consisting by [SbX3(HDTOA)(1.5)] building blocks. The octahedral geometric demand of the metal center is covered by three halides and three sulfur atoms from three different HDTOA ligands with facial conformation in both complexes. Each ligand bridged two metal centers of two units, through sulfur donor atoms, acting as bi-dentate bridging ligand. Complexes 1 and 2 were also tested for in vitro cytotoxic activity against human breast adenocarcinoma (MCF-7) and human cervical adenocarcinoma (HeLa) cells. Principal components analysis (PCA) was performed to discriminate the significant physicochemical molecular descriptors while regression analysis successfully related the experimental inhibitory concentrations, (IC50) to the independent variables indexed by PCA. The calculated IC50 values are satisfactorily compared with the measured inhibitory activity of the complexes. (C) 2013 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipNamik Kemal University Scientific Research ProjectNamik Kemal University [NKUBAP.00.10.AR.12.11]; European UnionEuropean Commission; Adam Mickiewicz Fundation
dc.description.sponsorshipI.I.O acknowledges the financial support from Namik Kemal University Scientific Research Project (Project No.NKUBAP.00.10.AR.12.11). A.M.O is a scholar of the project Scholarship support for Ph.D. students specializing in majors strategic for Wielkopolska's development, sub-measure 8.2.2 Human Capital Operational Programme, co-financed by European Union under the European Social Fund. A.M.O is also supported by the Adam Mickiewicz Fundation during the academic year 2013/2014 which is acknowledged.
dc.identifier.doi10.1016/j.poly.2013.12.025
dc.identifier.endpage179
dc.identifier.issn0277-5387
dc.identifier.scopus2-s2.0-84893187348
dc.identifier.scopusqualityQ2
dc.identifier.startpage172
dc.identifier.urihttps://doi.org/10.1016/j.poly.2013.12.025
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7182
dc.identifier.volume70
dc.identifier.wosWOS:000332142600025
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖztürk, İbrahim İsmet
dc.institutionauthorÜrgüt, Ozan
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPolyhedron
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntimony(III) halide
dc.subjectBi-dentate substitute dithiooxamide ligand
dc.subjectSpectroscopic characterization
dc.subjectCrystal structures
dc.subjectStructure activity relationship (SAR)
dc.subjectCytotoxicity
dc.subjectPCA
dc.subjectOxamide Metal-Complexes
dc.subjectMolecular-Structures
dc.subjectBiological-Activity
dc.subjectDiphenylantimony(Iii) Derivatives
dc.subjectDithiocarbamate Ligands
dc.subjectCoordination Chemistry
dc.subjectChloride Complexes
dc.subjectCrystal-Structure
dc.subjectDonor Ligands
dc.subjectCl
dc.titleSynthesis, structural characterization and cytostatic properties of N,N-dicyclohexyldithiooxamide complexes of antimony(III) halides (SbX3, X: Br or I)
dc.typeArticle

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