Oxidative stress in dogs during mid-gestation abortion: Fetal and maternal antioxidant alterations with clinical and hematological features

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dc.authorscopusid23985710500
dc.authorscopusid56086542900
dc.authorscopusid55921065100
dc.authorscopusid6507171811
dc.contributor.authorÖzalp, G. R.
dc.contributor.authorGül, Z.
dc.contributor.authorSeyidoğlu, Nilay
dc.contributor.authorBüyüküysal, L.
dc.date.accessioned2023-04-20T08:02:30Z
dc.date.available2023-04-20T08:02:30Z
dc.date.issued2022
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractThe present study aimed to evaluate the GSH and MDA levels in dog???s serum and vital organs of aborted fetuses, after application of two abortifacient. Animals of group I (n = 6) were treated twice with subcutaneous injection of 10 mg/kg aglepristone and group II (n = 3) received prostaglandin F2?? at a dose of 125 ??g/kg every 12 hours until abortion process completed. Hematologic examinations and sedimentation rates were performed of bitches. The duration between the first occurrence of vaginal discharge to first expulsion of fetuses ranged between 14-29 hours (mean: 22.6??5.5 h) and 24-33 hours in group I and II, respectively. Both treatments significantly increased the serum MDA levels (P<0.01); however aglepristone increased the MDA levels throughout the study, prostaglandin enhanced plasma MDA levels only on day 1. GSH levels were significantly lower in aglepristone-treated bitches than prostaglan-din-treated animals (P 0.05). The treatments resulted in similar MDA levels in liver and heart tissues (P 0.05). GSH levels in kidney, muscle and heart tissues did not differ between groups (P>0.05), aglepristone resulted reduced GSH levels in liver tissue (P<0.05). High MDA levels could be evaluated as a useful marker for fetal suffering in pregnancy controls. The MDA and GSH levels, measured in vital organs of fetuses, could suggest possible toxic effects of aborti-facients in newborns, as both medical agents are being used in parturition induction.
dc.description.sponsorshipDepartment of Psychiatry Yale Tobacco Center of Regulatory Science
dc.description.sponsorshipWe gratefully acknowledge Dr. Deniz Bagdas, from Department of Psychiatry Yale Tobacco Center of Regulatory Science, Yale University, USA for technical support with measurements and statistical evaluation
dc.identifier.doi10.12681/jhvms.26307
dc.identifier.endpage4048
dc.identifier.issn1792-2720
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85134398486
dc.identifier.scopusqualityQ3
dc.identifier.startpage4041
dc.identifier.urihttps://doi.org/10.12681/jhvms.26307
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10965
dc.identifier.volume73
dc.identifier.wosWOS:000825157800017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSeyidoğlu, Nilay
dc.language.isoen
dc.publisherHellenic Veterinary Medical Soc
dc.relation.ispartofJournal of the Hellenic Veterinary Medical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPregnancy Termination
dc.subjectMalondialdehyde
dc.subjectReduced Glutathione
dc.subjectProstaglandin
dc.subjectAglepristone
dc.subjectDog
dc.subjectProgesterone Antagonist Aglepristone
dc.subjectPregnancy Termination
dc.subjectUnwanted Pregnancy
dc.subjectMidterm Pregnancy
dc.subjectDopamine Agonist
dc.subjectVitamin-A
dc.subjectInduction
dc.subjectCombination
dc.subjectBitches
dc.subjectCloprostenol
dc.titleOxidative stress in dogs during mid-gestation abortion: Fetal and maternal antioxidant alterations with clinical and hematological features
dc.typeArticle

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