Beneficial effects of sennoside B on pentylenetetrazole-induced seizures in rats

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dc.authorscopusid58172491300
dc.authorscopusid55469991100
dc.contributor.authorŞahin, Hüseyin
dc.contributor.authorErbaş, O.
dc.date.accessioned2023-05-06T17:22:12Z
dc.date.available2023-05-06T17:22:12Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalı
dc.description.abstractBackground: Epilepsy is a common disorder affecting approximately 50 million people worldwide. Oxidative stress is known to play an important role in the pathophysiology of diseases, including epilepsy. In this study, we investigated the effects of sennoside B on PTZ-induced seizures in rats. Method: The rats were grouped into Group Electroencephalography and Group Behavioral. Both Groups were divided into eight subgroups, and these subgroups were compared in terms of the time of first myoclonic jerk, Racine’s Convulsion Scale, malondialdehyde levels, and brain superoxide dismutase activity. The experimental seizure model was performed with pentylenetetrazol. Results: The spike percentage was significantly lower in groups that received sennoside B, and this beneficial effect was shown to be associated with the dose of sennoside B received. The RCS score was lower and the FJM onset time was higher in the sennoside B-administered groups. Additionally, brain MDA and brain aquaporin-3 levels were lower and brain SOD activity was higher in the sennoside-administered groups. Conclusions: The present study shows the beneficial effects of sennoside B on PTZ-induced convulsion in rats. It is considered that sennoside B which is a natural and safe product would be a good candidate for strengthening the management of epilepsy without serious side effects. © The Author(s) 2023.
dc.identifier.doi10.1177/09603271231168764
dc.identifier.issn0960-3271
dc.identifier.pmid37021362
dc.identifier.scopus2-s2.0-85151796801
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1177/09603271231168764
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12112
dc.identifier.volume42
dc.identifier.wosWOS:000963787800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞahin, Hüseyin
dc.language.isoen
dc.publisherSAGE Publications Ltd
dc.relation.ispartofHuman and Experimental Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAquaporin
dc.subjectepilepsy
dc.subjectexperimental
dc.subjectsennoside B
dc.subjectanticonvulsive agent
dc.subjectpentetrazole
dc.subjectadverse event
dc.subjectanimal
dc.subjectdisease model
dc.subjectepilepsy
dc.subjectrat
dc.subjectseizure
dc.subjectSprague Dawley rat
dc.subjectAnimals
dc.subjectAnticonvulsants
dc.subjectDisease Models, Animal
dc.subjectEpilepsy
dc.subjectPentylenetetrazole
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectSeizures
dc.subjectSennosides
dc.titleBeneficial effects of sennoside B on pentylenetetrazole-induced seizures in rats
dc.typeArticle

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