Beneficial effects of sennoside B on pentylenetetrazole-induced seizures in rats
Yükleniyor...
Dosyalar
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
SAGE Publications Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Epilepsy is a common disorder affecting approximately 50 million people worldwide. Oxidative stress is known to play an important role in the pathophysiology of diseases, including epilepsy. In this study, we investigated the effects of sennoside B on PTZ-induced seizures in rats. Method: The rats were grouped into Group Electroencephalography and Group Behavioral. Both Groups were divided into eight subgroups, and these subgroups were compared in terms of the time of first myoclonic jerk, Racine’s Convulsion Scale, malondialdehyde levels, and brain superoxide dismutase activity. The experimental seizure model was performed with pentylenetetrazol. Results: The spike percentage was significantly lower in groups that received sennoside B, and this beneficial effect was shown to be associated with the dose of sennoside B received. The RCS score was lower and the FJM onset time was higher in the sennoside B-administered groups. Additionally, brain MDA and brain aquaporin-3 levels were lower and brain SOD activity was higher in the sennoside-administered groups. Conclusions: The present study shows the beneficial effects of sennoside B on PTZ-induced convulsion in rats. It is considered that sennoside B which is a natural and safe product would be a good candidate for strengthening the management of epilepsy without serious side effects. © The Author(s) 2023.
Açıklama
Anahtar Kelimeler
Aquaporin, epilepsy, experimental, sennoside B, anticonvulsive agent, pentetrazole, adverse event, animal, disease model, epilepsy, rat, seizure, Sprague Dawley rat, Animals, Anticonvulsants, Disease Models, Animal, Epilepsy, Pentylenetetrazole, Rats, Rats, Sprague-Dawley, Seizures, Sennosides
Kaynak
Human and Experimental Toxicology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
42
