Crimean-Congo hemorrhagic fever virus in tortoises and Hyalomma aegyptium ticks in East Thrace, Turkey: Potential of a cryptic transmission cycle

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dc.authorscopusid15769247000
dc.authorscopusid57189693899
dc.authorscopusid56543627500
dc.authorscopusid6506583537
dc.authorscopusid8416126500
dc.authorscopusid57211527870
dc.authorscopusid8864079300
dc.contributor.authorKar, Sırrı
dc.contributor.authorRodriguez, S.E.
dc.contributor.authorAkyıldız, Gürkan
dc.contributor.authorCajimat, M.N.B.
dc.contributor.authorBircan, Rifat
dc.contributor.authorMears, M.C.
dc.contributor.authorKeleş, A.G.
dc.date.accessioned2022-05-11T14:03:12Z
dc.date.available2022-05-11T14:03:12Z
dc.date.issued2020
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractBackground: Recent reports have demonstrated the presence of Crimean-Congo hemorrhagic fever virus (CCHFV) genomic material in Hyalomma aegyptium ticks feeding primarily on tortoises belonging to the genus Testudo. This raises the question if these ticks and their hosts play a role in the natural transmission dynamics of CCHFV. However, the studies are limited, and assessing the relevance of H. aegyptium in perpetuating the virus in nature, and a potential spillover to humans remains unknown. This study aimed to detect CCHFV in H. aegyptium ticks and their tortoise hosts in the East Thrace region of Turkey, where H. aegyptium is the most common human-biting tick and where a high density of tortoises of the genus Testudo can be found. Methods: During the study period, 21 blood samples from different tortoises (2 T. hermanni and 19 T. graeca), 106 tick pools (containing 448 males, 152 females, 93 nymphs and 60 larvae) collected from 65 tortoises (5 T. hermanni and 60 T. graeca), 38 adult unfed questing ticks (25 males and 13 females, screened individually) and 14 pools (containing 8 nymphs and 266 larvae) of immature unfed questing ticks collected from the ground were screened for CCHFV genome by nested PCR and partial genomes sequenced. Results: As a result of the screening of these 179 samples, 17 (9.5%) were detected as positive as follows: 2 of 21 blood samples (9.52%), 13 (containing 18 nymphs in 3 pools, and 52 males and 8 females in 10 pools) of 106 tick pools from tortoises (12.26%), and 2 of 38 adult questing ticks (5.26%). No positive result was determined in 14 pools of immature questing ticks. Conclusions: Previous studies have shown that reptiles can participate in the transmission of arthropod-borne viruses, but they may contribute to different aspects of the disease ecology and evolution of tick-borne viral pathogens. Our results indicate the presence of CCHFV in questing and feeding H. aegyptium ticks as well as tortoise hosts. This may indicate that CCHFV circulates in a cryptic transmission cycle in addition to the primary transmission cycle that could play a role in the natural dynamic of the virus and the transmission to humans.[Figure not available: see fulltext.] © 2020 The Author(s).
dc.identifier.doi10.1186/s13071-020-04074-6
dc.identifier.issn1756-3305
dc.identifier.issue1en_US
dc.identifier.pmid32307010
dc.identifier.scopus2-s2.0-85083811810
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s13071-020-04074-6
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4640
dc.identifier.volume13
dc.identifier.wosWOS:000529211900002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkyıldız, Gürkan
dc.institutionauthorBircan, Rifat
dc.language.isoen
dc.publisherBioMed Central Ltd.
dc.relation.ispartofParasites and Vectors
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCrimean-Congo hemorrhagic fever virus
dc.subjectCryptic transmission cycle
dc.subjectHyalomma aegyptium
dc.subjectThrace
dc.subjectTortoise
dc.subjectTurkey
dc.subjectadult
dc.subjectArticle
dc.subjectCrimean-Congo hemorrhagic fever virus
dc.subjectfemale
dc.subjectHyalomma
dc.subjectHyalomma aegyptium
dc.subjectmale
dc.subjectnonhuman
dc.subjectTestudo graeca
dc.subjectTestudo hermanni
dc.subjecttortoise
dc.subjectTurkey (republic)
dc.subjectvirus cell interaction
dc.subjectvirus genome
dc.subjectvirus transmission
dc.subjectanimal
dc.subjectarachnid vector
dc.subjectCrimean Congo hemorrhagic fever
dc.subjectdisease carrier
dc.subjectepidemiology
dc.subjectgenetics
dc.subjectisolation and purification
dc.subjectparasitology
dc.subjectphylogeny
dc.subjectpolymerase chain reaction
dc.subjecttick
dc.subjectturkey (bird)
dc.subjectturtle
dc.subjectvirology
dc.subjectzoonosis
dc.subjectvirus DNA
dc.subjectAnimals
dc.subjectArachnid Vectors
dc.subjectDisease Reservoirs
dc.subjectDNA, Viral
dc.subjectHemorrhagic Fever Virus, Crimean-Congo
dc.subjectHemorrhagic Fever, Crimean
dc.subjectPhylogeny
dc.subjectPolymerase Chain Reaction
dc.subjectTicks
dc.subjectTurkey
dc.subjectTurtles
dc.subjectZoonoses
dc.titleCrimean-Congo hemorrhagic fever virus in tortoises and Hyalomma aegyptium ticks in East Thrace, Turkey: Potential of a cryptic transmission cycle
dc.typeArticle

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