Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures

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dc.contributor.authorKaya, Yasin Emre
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorŞirin, Duygu Yaşar
dc.contributor.authorYaman, Onur
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorAteş, Özkan
dc.date.accessioned2022-05-11T14:12:25Z
dc.date.available2022-05-11T14:12:25Z
dc.date.issued2020
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractAbstractAim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue cells and the extracellular matrix.Material and Methods: Cartilage tissues of patients (n = 8) were used for the preparation of primary cell cultures. Tigecycline-treated cell cultures served as the study group. Non-treated cell cultures served as the control group. Analyses were performed at 0, 24, 48, and 72 h in both groups. The results obtained were statistically evaluated. The alpha significance value was determined to be 0.05.Results: Proliferation remained unchanged in the tigecycline-treated cell cultures. The gene expressions of the markers involved in anabolic pathways increased in the tigecycline-treated cell cultures. The results obtained were statistically significant (P < 0.05).Conclusion: Although tigecycline had no toxic effect on the chondrocyte cell cultures and caused no damage to the extracellular matrix, the present study was performed in an in vitro environment.
dc.identifier.doi10.5455/annalsmedres.2019.11.780
dc.identifier.endpage1087
dc.identifier.issn2636-7688
dc.identifier.issn2636-7688
dc.identifier.issue4en_US
dc.identifier.startpage1082
dc.identifier.trdizinidTXpZeE9URXlNZz09
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2019.11.780
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpZeE9URXlNZz09
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5547
dc.identifier.volume27
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorŞirin, Duygu Yaşar
dc.institutionauthorKaraarslan, Numan
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleInvestigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures
dc.typeArticle

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