Investigation of relationship of the mitochondrial DNA 16189 T > C polymorphism with metabolic syndrome and its associated clinical parameters in Turkish patients

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dc.authorid0000-0002-1100-765X
dc.authorid0000-0002-1100-765X
dc.authorid0000-0002-6044-1372
dc.authorid0000-0001-6222-7882
dc.authorscopusid6602491471
dc.authorscopusid57195257114
dc.authorscopusid7006479102
dc.authorscopusid37110733000
dc.authorscopusid6602211238
dc.authorscopusid6602175753
dc.authorscopusid7005139386
dc.authorwosidAkkiprik, Mustafa/A-6453-2017
dc.authorwosidAkkiprik, Mustafa/AAD-6167-2020
dc.contributor.authorAral, Cenk
dc.contributor.authorAkkiprik, Mustafa
dc.contributor.authorÇaglayan, Sinan
dc.contributor.authorAtabey, Zehra
dc.contributor.authorÖzışık, Gökhan
dc.contributor.authorBekiroglu, Nuray
dc.contributor.authorÖzer, Ayşe
dc.date.accessioned2022-05-11T14:28:27Z
dc.date.available2022-05-11T14:28:27Z
dc.date.issued2011
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractOBJECTIVE: Mitochondrial DNA (mtDNA) polymorphisms have been implicated in the pathophysiology of human diseases. Among them, a T>C nucleotide transition on the 16189 nucleotide position of mtDNA has been studied in several metabolic diseases including diabetes and obesity. In this study we aimed to investigate the association of this polymorphism among Turkish metabolic syndrome patients. DESIGN: A total of 220 cases (70 MetS patients and 150 healthy control subjects) were evaluated for their mtDNA 16189 variant by PCR-RFLP technique. In addition, clinical and biochemical variables, such as cholesterol levels, body fat percentage, insulin resistance and presence of type II diabetes, were also evaluated. RESULTS: Overall frequency of polymorphic C allele was determined as 0.19 without a significant association with type II diabetes and metabolic syndrome. This may be partly due to ethnical differences of populations studied and may also be related to other genetic and environmental factors. Moreover, there were no significant associations with biochemical variables among metabolic syndrome patients, except LDL and suppressed cortisol (sup-cortisol) levels. Low levels of LDL and sup-cortisol were significantly associated with the mtDNA 16189 variant, though the biochemical mechanism underlying this effect is not clear. CONCLUSIONS: This is the first study involving a Turkish population on the mtDNA 16189 T>C polymorphism. Further studies with larger cohorts will be needed to elucidate its relation with metabolic syndrome as well as lipid metabolism.
dc.description.sponsorshipNamik Kemal University Research Foundation (NKUBAP)Namik Kemal University; Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)
dc.description.sponsorshipWe express our gratitude to Dr. Nadim Yilmazer for revising the English manuscript. This study was supported in part by grants from the Namik Kemal University Research Foundation (NKUBAP) and from the Scientific and Technological Research Council of Turkey (TUBITAK).
dc.identifier.doi10.14310/horm.2002.1321
dc.identifier.endpage303
dc.identifier.issn1109-3099
dc.identifier.issue4en_US
dc.identifier.pmid22281886
dc.identifier.scopus2-s2.0-84855493020
dc.identifier.scopusqualityQ2
dc.identifier.startpage298
dc.identifier.urihttps://doi.org/10.14310/horm.2002.1321
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6832
dc.identifier.volume10
dc.identifier.wosWOS:000299347900006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAral, Cenk
dc.language.isoen
dc.publisherHellenic Endocrine Soc
dc.relation.ispartofHormones-International Journal of Endocrinology and Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetes
dc.subjectMetabolic syndrome
dc.subjectMitochondrial DNA
dc.subjectType-2 Diabetes-Mellitus
dc.subjectBody-Mass Index
dc.subjectInsulin-Resistance
dc.subjectVariant
dc.subjectDisease
dc.subjectGlucose
dc.subjectGenome
dc.subjectPhenotypes
dc.subjectSequence
dc.subjectGrowth
dc.titleInvestigation of relationship of the mitochondrial DNA 16189 T > C polymorphism with metabolic syndrome and its associated clinical parameters in Turkish patients
dc.typeArticle

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