Should the cardiac rhythm be monitored following administration of zoledronic acid in elderly osteoporotic women?

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dc.authorid0000-0003-2003-6337
dc.authorscopusid57191926529
dc.authorscopusid55376303200
dc.authorscopusid35197435300
dc.authorscopusid6505680586
dc.authorscopusid26536840100
dc.authorscopusid23986422400
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.authorwosidYILMAZ, Ibrahim/H-6199-2019
dc.contributor.authorYıldırım Güzelant, Aliye
dc.contributor.authorSarıfakıo?lu, Ayşe Banu
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorSaraçoğlu Varol, Gamze
dc.contributor.authorTaşdemir, Nicel
dc.date.accessioned2022-05-11T14:07:39Z
dc.date.available2022-05-11T14:07:39Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Halk Sağlığı Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractObjectives: This study aims to investigate the possible undesirable cardiac effects associated with zoledronic acid treatment in elderly osteoporotic women. Patients and methods: Between October 2010 and December 2013, a total of 33 osteoporotic female patients (mean age 73.3 +/- 6.9 years; range 65 to 85 years) were included in this prospective study. Bone mineral density of the patients was measured. Biochemical and hormonal analyzes were performed. Electrocardiograms were taken. These analyses were repeated twice at one hour and 10 days after the administration of the zoledronic acid. Results: Pre- and post-treatment electrocardiography findings within the first hour were found to be within normal limits. P-wave dispersion and RR intervals, which were found to be normal before administration of the drug, tended to significantly increase at 10 days following the administration (p=0.029 and p=0.031, respectively). Using a cut-off value of 50 msec, alterations in corrected QT dispersion were found to be statistically significant (p=0.004). Conclusion: Based on our study findings, an increased ventricular arrhythmia risk should be also possibly considered as well as well-known atrial arrhythmic adverse effects of zoledronic acid. Therefore, we recommend a thorough examination for cardiac arrhythmia before the drug administration.
dc.identifier.doi10.5606/tftrd.2016.78871
dc.identifier.endpage221
dc.identifier.issn1302-0234
dc.identifier.issn1308-6316
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84985919253
dc.identifier.scopusqualityN/A
dc.identifier.startpage214
dc.identifier.urihttps://doi.org/10.5606/tftrd.2016.78871
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5167
dc.identifier.volume62
dc.identifier.wosWOS:000384958700003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYıldırım Güzelant, Aliye
dc.institutionauthorSarıfakıo?lu, Ayşe Banu
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorSaraçoğlu Varol, Gamze
dc.institutionauthorTaşdemir, Nicel
dc.language.isoen
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayincilik
dc.relation.ispartofTurkiye Fiziksel Tip Ve Rehabilitasyon Dergisi-Turkish Journal of Physical Medicine and Rehabilitation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdverse effect
dc.subjectcardiac arrhythmia
dc.subjectosteoporosis
dc.subjecttoxicity
dc.subjectzoledronic acid
dc.subjectQt Interval
dc.subjectBisphosphonates
dc.subjectRisk
dc.subjectPopulation
dc.subjectDispersion
dc.subjectMortality
dc.subjectProlongation
dc.subjectDiagnosis
dc.titleShould the cardiac rhythm be monitored following administration of zoledronic acid in elderly osteoporotic women?
dc.title.alternativeYaşlı osteoporotik kadınlarda zoledronik asit uygulaması sonrası kalp ritmi takip edilmeli midir?]
dc.typeArticle

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