Structural architectures and biological properties of main group bismuth(III) iodide complexes with heterocyclic thioamides

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dc.authorscopusid36785856200
dc.authorscopusid46860923200
dc.authorscopusid6602925165
dc.authorscopusid57196276440
dc.authorscopusid6602706096
dc.contributor.authorÖztürk, İbrahim İsmet
dc.contributor.authorBanti, Christina N.
dc.contributor.authorHadjikakou, Sotiris K.
dc.contributor.authorPanagiotou, Nikos
dc.contributor.authorTasiopoulos, Anastasios J.
dc.date.accessioned2022-05-11T14:03:22Z
dc.date.available2022-05-11T14:03:22Z
dc.date.issued2019
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractA series of mononuclear, dinuclear and polynuclear bismuth(III) iodide complexes (1–5) bearing heterocyclic thioamide ligands, 2-mercapto-3,4,5,6-tetrahydro-pyrimidine (tHPMT), 2-mercapto-benzimidazole (MBZIM), 2-mercapto-1-methylimidazole (MMI), 2-mercaptobenzothiazole (MBZT) and 2-mercaptopyridine (PYT), have been synthesized and characterized by melting point, elemental analysis, FT-IR spectroscopy, Raman spectroscopy, 1H, 13C NMR spectroscopy, UV–Vis spectroscopy and Thermal Gravimetry-Differential Thermal Analysis (TG-DTA). Moreover, the crystal structures of 1–5 have been also determined with single crystal X-ray diffraction analysis. The use of the above mentioned heterocyclic thioamide ligands have allowed synthesis of the first examples of bismuth(III) iodide thioamide complexes. {[BiI3(tHPMT)3]} (1) is the first structural example of a neutral mononuclear bismuth(III) iodide complex with octahedral geometry around the bismuth(III) ion with meridional conformation. {[BiI2(µ2-I)(MBZIM)2]2} (2) is the first example of a dinuclear bismuth(III) iodide complex with octahedral geometry around the bismuth(III) ion with trans-S/cis-I arrangement. {[BiI(µ2-I)2(MMI)]n} (3) and {[BiI(µ2-I)2(MBZT)]n·CH3OH} (4) are the first examples of the polynuclear bismuth(III) iodide complexes with octahedral geometry around the bismuth(III) ions. The ligand molecules are coordinated via the thione sulfur atoms in both complexes but in complex 3, ligand molecules are trans to each other in polymeric chain while, in complex 4, ligand molecules are cis to each other in polymeric chain. {[BiI(µ2-S,N-PYT)2]n} (5) is the first example of a polynuclear bismuth(III) iodide complex with pentagonal bipyramidal geometry around the bismuth(III) ions. The seven coordinate bismuth(III) atom has a N2S4I-donor set consisting of one iodine atom and two chelating and bridging ?2-S,N (?2-S:?1-N) pyridine-2-thionate anions. Complexes 1–5 were evaluated for their in vitro cytotoxic activity against human adenocarcinoma cervix (HeLa) and breast (MCF-7) cancer cells. The toxicity of the complexes was studied against human fetal lung fibroblast cells (MRC-5). The influence of 1–5, upon the catalytic peroxidation of the linoleic acid by the enzyme lipoxygenase (LOX), was evaluated experimentally. © 2019 Elsevier B.V.
dc.description.sponsorship114Z457; Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK
dc.description.sponsorshipI.I.O acknowledges the financial support from The Scientific and Technological Research Council of Turkey (TUBITAK, Project No. 114Z457 ).
dc.identifier.doi10.1016/j.ica.2019.119094
dc.identifier.issn0020-1693
dc.identifier.scopus2-s2.0-85071726630
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.ica.2019.119094
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4681
dc.identifier.volume497
dc.identifier.wosWOS:000487820000020
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖztürk, İbrahim İsmet
dc.language.isoen
dc.publisherElsevier S.A.
dc.relation.ispartofInorganica Chimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBismuth(III) iodide
dc.subjectCytotoxicity
dc.subjectHeterocyclic thioamides
dc.subjectLipoxygenase inhibition
dc.subjectMain group elements
dc.subjectArchitectural acoustics
dc.subjectAtoms
dc.subjectCell culture
dc.subjectChelation
dc.subjectComplexation
dc.subjectCytotoxicity
dc.subjectDifferential thermal analysis
dc.subjectGeometry
dc.subjectIons
dc.subjectLanthanum compounds
dc.subjectLigands
dc.subjectLinoleic acid
dc.subjectMolecules
dc.subjectNuclear magnetic resonance spectroscopy
dc.subjectOrganic compounds
dc.subjectPolymers
dc.subjectSingle crystals
dc.subjectSpectrum analysis
dc.subjectSynthesis (chemical)
dc.subjectX ray powder diffraction
dc.subject2-mercapto-benzimidazole
dc.subjectBismuth(III)
dc.subjectHuman fetal lung fibroblast
dc.subjectLipoxygenases
dc.subjectMain-group elements
dc.subjectPentagonal bipyramidal geometry
dc.subjectSingle crystal X-ray diffraction analysis
dc.subjectThioamides
dc.subjectBismuth compounds
dc.titleStructural architectures and biological properties of main group bismuth(III) iodide complexes with heterocyclic thioamides
dc.typeArticle

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