Antimony(III) halide compounds of thioureas: Structures and biological activity

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dc.authorid0000-0003-3264-2406
dc.authorid0000-0001-9556-6266
dc.authorid0000-0003-0377-2260
dc.authorid0000-0003-3164-0038
dc.authorid0000-0001-6727-2711
dc.authorid0000-0001-7202-9169
dc.authorid0000-0002-4804-3822
dc.authorscopusid56193039200
dc.authorscopusid36785856200
dc.authorscopusid46860923200
dc.authorscopusid6507202525
dc.authorscopusid14525091600
dc.authorscopusid6602706096
dc.authorscopusid57209326301
dc.authorwosidKourkoumelis, Nikolaos/B-8555-2009
dc.authorwosidHadjikakou, Sotiris K./I-2909-2019
dc.authorwosidOzturk, Ibrahim Ismet/K-1352-2013
dc.authorwosidGrze?kiewicz, Anita/E-1315-2018
dc.contributor.authorHan, A.
dc.contributor.authorÖztürk, İbrahim İsmet
dc.contributor.authorBanti, Christina N.
dc.contributor.authorKourkoumelis, Nikolaos
dc.contributor.authorManoli, Maria
dc.contributor.authorTasiopoulos, Anastasios J.
dc.contributor.authorHadjikakou, Sotiris K.
dc.date.accessioned2022-05-11T14:29:53Z
dc.date.available2022-05-11T14:29:53Z
dc.date.issued2014
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractAntimony(III) halide compounds (SbX3, X = Cl and Br) of thioureas; tetramethylthiourea (TMTU), N,N'-diethylthiourea (DETU) and 1,3-diisopropy1-2-thiourea (DIPTU) of formulae {[SbCl3(TMTU)](n)} (1), {[SbBr3(TMTU)](n)} (2), {[mer-SbCl3(DIPTU)(3))] [fac-SbCl3(DIPTU)(3)] C6H6} (3) and {[SbBr2(DETU)(2)](+)center dot Br-}(n) (4) were synthesized. The complexes were characterized by their melting point, elemental analysis, FT-IR spectroscopy, FT-Raman spectroscopy, H-1 and C-13 NMR spectroscopy and Thermal Gravimetry-Differential Thermal Analysis (TG-DTA). The crystal and molecular structures of complexes 2-4 were determined with single crystal X-ray diffraction analysis. Compounds 1 and 2 are polymers with pseudo-trigonal bipyramidal (Psi-TBP) geometry in each monomeric unit. Compound 3 is a monomer with octahedral (Oh) geometry around Sb(III). Two different coordination modes of the ligands around antimony ions are observed in 3 forming two units. One with meridional orientation and the other with facial one. This complex is the first example of polymeric antimony(III) where two sequential antimony atoms have two different coordination modes. Two sulfur atoms and two bromines form a pseudotrigonal bipyramidal cationic [SbBr2(L)(2)](+) part with a bromide as counter anion in complex 4. Complexes 1-4 and their ligands were evaluated for their in vitro cytotoxic activity against human breast adenocarcinoma (MCF-7) and human cervical adenocarcinoma (HeLa) cells. Principal components analysis (PCA) was performed to discriminate the significant physicochemical molecular descriptors while regression analysis successfully relates the experimental inhibitory concentrations, (IC50) to the independent variables indexed by PCA. (C) 2014 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipNamik Kemal UniversityNamik Kemal University [NKUBAP.00.10.YL.13.05]; Adam Mickiewicz Fundation
dc.description.sponsorshipThis research was carried out in partial fulfillment of the requirements for the master thesis of A.H. under the supervision of I.I.O. I.I.O. and A.H. acknowledge the financial support from Namik Kemal University Scientific Research Project (Project No. NKUBAP.00.10.YL.13.05). A.M.O is supported by the Adam Mickiewicz Fundation during the academic year 2013/2014 which is acknowledged. The cell studies were carried out in partial fulfillment of the requirements for the master thesis of Mrs C.N.B within the graduate program in Bioinorganic Chemistry.
dc.identifier.doi10.1016/j.poly.2014.05.014
dc.identifier.endpage160
dc.identifier.issn0277-5387
dc.identifier.scopus2-s2.0-84901797157
dc.identifier.scopusqualityQ2
dc.identifier.startpage151
dc.identifier.urihttps://doi.org/10.1016/j.poly.2014.05.014
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7163
dc.identifier.volume79
dc.identifier.wosWOS:000340313800018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorHan, A.
dc.institutionauthorÖztürk, İbrahim İsmet
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPolyhedron
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntimony(III) halide
dc.subjectThioureas
dc.subjectCrystal structures
dc.subjectCytotwdcity
dc.subjectPCA
dc.subjectDiphenylantimony(Iii) Derivatives
dc.subjectIn-Vitro
dc.subjectComplexes
dc.subjectLeukemia
dc.subjectChloride
dc.subjectCrystal
dc.subjectLeishmaniasis
dc.subjectThioamides
dc.subjectBismuth
dc.titleAntimony(III) halide compounds of thioureas: Structures and biological activity
dc.typeArticle

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