Comparison of Cytotoxic Flow Cytometric Cross Match With Complement Dependent Lymphocytotoxicity and Flow Cytometric Cross Match in Renal Transplant Patients
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier USA
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Cytotoxic flow cytometric crossmatch (cFCXM), identified by detecting complement-mediated cytotoxic cell death in addition to the capability of showing the alloantibodies binding onto lymphocytes at the same time, can reduce the necessary time and workload in evaluating alloantibodies. More data from clinical samples are needed for cFCXM to be accepted by tissue typing laboratories. In this study, we compared cFCXM with complement-dependent lymphocytotoxicity and standard flow cytometric crossmatch in 41 renal pretransplant patients. A comparison of the obtained data was performed using Spearman's correlation test. We found that cFCXM showed no statistically significant differences with complement-dependent lymphocytotoxicity and flow cytometric crossmatch. We believe that cFCXM can be used in clinical laboratories in the near future following intra-laboratory validation. © 2019 Elsevier Inc.
Açıklama
Anahtar Kelimeler
Article, blood examination, clinical laboratory, complement dependent lymphocytotoxicity, controlled study, correlation coefficient, cytotoxic flow cytometric crossmatch, cytotoxicity test, flow cytometric crossmatch, flow cytometry, graft recipient, human, human cell, intermethod comparison, kidney transplantation, priority journal, comparative study, cytotoxicity test, female, flow cytometry, histocompatibility test, immunology, kidney transplantation, male, procedures, alloantibody, Cytotoxicity Tests, Immunologic, Female, Flow Cytometry, Histocompatibility Testing, Humans, Isoantibodies, Kidney Transplantation, Male
Kaynak
Transplantation Proceedings
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
51
Sayı
4
