Protective effects of hesperetin on lipopolysaccharide-induced acute lung injury in a rat model

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dc.authorscopusid23982435200
dc.authorscopusid57225839620
dc.authorscopusid56727936300
dc.authorscopusid56816914100
dc.authorscopusid57212512972
dc.authorscopusid8855691800
dc.authorscopusid56047982200
dc.contributor.authorKaya, S.
dc.contributor.authorKaya, S.A.
dc.contributor.authorPolat, E.
dc.contributor.authorErboğa, Zeynep Fidanol
dc.contributor.authorDuran, Y.
dc.contributor.authorPolat, Fatin Rüştü
dc.contributor.authorKaraboğa, İhsan
dc.date.accessioned2022-05-11T14:01:34Z
dc.date.available2022-05-11T14:01:34Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göğüs Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü
dc.description.abstractBackground: In this experimental study, we aimed to investigate the effects of hesperetin, a natural flavonoid, on a lipopolysaccharideinduced acute lung injury model in rats. Methods: Between March 2019 and May 2019, a total of 18 adult male Wistar albino rats, weighing approximately 250 to 300 g, were randomly divided into three groups as control, lipopolysaccharide, and lipopolysaccharide + hesperetin groups (n=6 in each group). The wet/dry weight ratio of lung tissue was determined. Histopathological changes were examined using light and scanning electron microscopy. Pulmonary nuclear factor-kappa beta, inducible nitric oxide synthase, and alpha-smooth muscle antigen activity were determined with indirect immunohistochemical methods. Pulmonary apoptosis was detected with the terminal deoxynucleotidyl transferase dUTP nick-end labeling method. Tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, and interleukin-10 concentrations were measured with enzyme-linked immunosorbent assay. Results: Treatment with hesperetin significantly improved the architecture of lung tissue and reduced the wet/dry weight ratio, nuclear factor-kappa beta, inducible nitric oxide synthase, and alphasmooth muscle antigen expression, pulmonary apoptosis, and levels of proinflammatory cytokines. Conclusion: Our study results suggest that hesperetin has a potent protective effect against lipopolysaccharide-induced acute lung injury in rats via suppression of the proinflammatory cytokine cascade, nuclear factor-kappa beta, signaling pathway activation, and apoptosis. © 2020 All right reserved by the Turkish Society of Cardiovascular Surgery.
dc.identifier.doi10.5606/tgkdc.dergisi.2020.18816
dc.identifier.endpage368
dc.identifier.issn1301-5680
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85085133382
dc.identifier.scopusqualityQ3
dc.identifier.startpage359
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2020.18816
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4438
dc.identifier.volume28
dc.identifier.wosWOS:000529820900020
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKaya, S.
dc.institutionauthorPolat, E.
dc.institutionauthorErboğa, Zeynep Fidanol
dc.institutionauthorDuran, Y.
dc.institutionauthorPolat, Fatin Rüştü
dc.institutionauthorKaraboğa, İhsan
dc.language.isoen
dc.publisherBaycinar Medical Publishing
dc.relation.ispartofTurkish Journal of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcute lung injury
dc.subjectInducible nitric oxide synthase
dc.subjectLipopolysaccharide
dc.subjectNuclear factor-kappa beta
dc.subjectPulmonary apoptosis
dc.subjectTumor necrosis factor-alpha
dc.titleProtective effects of hesperetin on lipopolysaccharide-induced acute lung injury in a rat model
dc.typeArticle

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