The effects of melatonin on liver functions in arsenic-induced liver damage

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dc.authorid0000-0002-2270-2965
dc.authorid0000-0003-2112-4056
dc.authorscopusid55624501100
dc.authorscopusid56715752200
dc.authorscopusid17433815200
dc.authorscopusid56388498400
dc.authorscopusid55858591400
dc.authorscopusid57193126335
dc.authorscopusid7102765266
dc.authorwosidBilir, Bülent/AAK-5656-2021
dc.authorwosidYilmaz, Ahsen/ABB-1083-2021
dc.contributor.authorBali, İlhan
dc.contributor.authorBilir, Bülent
dc.contributor.authorEmir, Seyfi
dc.contributor.authorTuran, Filiz
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorGökkuş, Tuba
dc.contributor.authorAydın, Murat
dc.date.accessioned2022-05-11T14:09:56Z
dc.date.available2022-05-11T14:09:56Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: Arsenic exposure is increasing in communities due to environmental pollution and industrial development. Arsenic is toxic to organ systems because it causes oxidative stress, enzymatic inhibition, and damage to protein structures. The liver, for example, is an organ that may be damaged by arsenic, and this damage may cause various clinical conditions like hepatic failure or cancer. Melatonin is a hormone that acts like an antioxidant, an anti-inflammatory agent, and a cytoprotective agent. In this study, we aimed to evaluate melatonin's protective effects on livers damaged by arsenic toxicity. Materials and Methods: Twenty-four Sprague-Dawley male rats were classified into three groups: a control group, an arsenic applied group, and an arsenic plus 10 mg/kg melatonin applied group. At the end of the fifteen-day experiment, the rats were sacrificed. Albumin, interleukin-6 (IL-6), total protein, alanine transaminase, aspartate transaminase, macrophage migration inhibitory factor, and monocyte chemotactic protein-1 measurements were obtained. Results: In rats with liver damage due to arsenic exposure, melatonin administration significantly decreased the levels of IL-6, macrophage migration inhibitory factor, and monocyte chemotactic protein-1 (p<0.001, p=0.02 and p=0.04, respectively). Conclusion: After evaluating liver enzymes and inflammatory markers, this study determined that melatonin exposure improves liver tissue damage caused by arsenic exposure, with the degree of improvement varying based on the levels of arsenic exposure.
dc.identifier.doi10.5152/UCD.2015.3224
dc.identifier.endpage237
dc.identifier.issn2564-6850
dc.identifier.issn2564-7032
dc.identifier.issue4en_US
dc.identifier.pmid28149117
dc.identifier.scopus2-s2.0-85011003465
dc.identifier.scopusqualityN/A
dc.identifier.startpage233
dc.identifier.urihttps://doi.org/10.5152/UCD.2015.3224
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5208
dc.identifier.volume32
dc.identifier.wosWOS:000392193500002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBali, İlhan
dc.institutionauthorBilir, Bülent
dc.institutionauthorEmir, Seyfi
dc.institutionauthorTuran, Filiz
dc.institutionauthorYılmaz, Ahsen
dc.institutionauthorGökkuş, Tuba
dc.institutionauthorAydın, Murat
dc.language.isoen
dc.publisherTurkish Surgical Assoc
dc.relation.ispartofTurkish Journal of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectArsenic
dc.subjectinterleukin-6
dc.subjectmacrophage migration inhibitory factor
dc.subjectmelatonin
dc.subjectmonocyte chemotactic protein 1
dc.subjectMigration-Inhibitory Factor
dc.subjectSerum-Levels
dc.subjectInjury
dc.subjectMice
dc.subjectInflammation
dc.subjectPrevention
dc.subjectStress
dc.subjectTarget
dc.subjectMouse
dc.subjectModel
dc.titleThe effects of melatonin on liver functions in arsenic-induced liver damage
dc.typeArticle

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