Protective Effects of Hesperetin Against Lipopolysaccharide-induced Acute Renal Injury in Rat

Basit Öğe Kaydı
dc.authorscopusid23982435200
dc.authorscopusid55838809000
dc.contributor.authorKaya, Serkan
dc.contributor.authorKaraboğa, İhsan
dc.date.accessioned2023-04-20T08:02:29Z
dc.date.available2023-04-20T08:02:29Z
dc.date.issued2022
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü
dc.description.abstractObjective: In this study, it was aimed to investigate the effects of hesperetin on renal transforming growth factor-beta 1 (TGF-beta 1) expression and apoptosis in rat lipopolysaccharide (LPS)-induced acute renal injury model. Methods: In the study, 18 adult male Wistar albino rats were used. Rats divided into three groups, respectively (n=6); control, LPS and LPS + hesperetin. Sepsis model was created with a singledose of LPS (Escherichia coli, O26: B6 serotype, Sigma-aldrich). LPS + hesperetin group was administered intragastrically with the aid of hesperetin oral gavage at a dose of 100 mg/kg, after LPS-induction. Twenty four hours after LPS administration, the rats were opened from the midline under ketamine-xylazine anesthesia and kidney tissue and cardiac blood were collected. Kidney tissue was examined with hematoxylin-eosin staining. TGF-beta 1 expression was determined by indirect immunohistochemical method. TUNEL method was used to determine renal apoptosis. Blood urea nitrogen (BUN) and creatinine levels in blood serum were determined using spectrophotometric methods. Results: Decreased histopathological changes, TGF-beta 1 expression and apoptosis were determined in the LPS + hesperetin group compared to the LPS group (p<0.05). In addition, a significant decrease in BUN and creatinine levels was observed in the LPS + hesperetin group compared to the LPS group (p<0.05). Conclusion: The data obtained show that in the LPS-induced rat sepsis model, hesperetin suppresses the expression of TGF-beta 1 in kidney tissue and provides a protective effect.
dc.identifier.doi10.4274/BMJ.galenos.2022.2022.2-16
dc.identifier.endpage257
dc.identifier.issn1305-9319
dc.identifier.issn1305-9327
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85133824768
dc.identifier.scopusqualityQ4
dc.identifier.startpage252
dc.identifier.trdizinid1165535
dc.identifier.urihttps://doi.org/10.4274/BMJ.galenos.2022.2022.2-16
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10954
dc.identifier.volume18
dc.identifier.wosWOS:000825327700020
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKaya, Serkan
dc.institutionauthorKaraboğa, İhsan
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofMedical Journal of Bakirkoy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLipopolysaccharide
dc.subjectAcute Kidney Injury
dc.subjectHesperetin
dc.subjectTransforming Growth Factor-Beta 1
dc.subjectRenal Apoptosis
dc.subjectAcute Kidney Injury
dc.subjectAcute Lung Injury
dc.subjectOxidative Stress
dc.subjectAntioxidant
dc.subjectApoptosis
dc.subjectEndotoxin
dc.subjectTlr4
dc.titleProtective Effects of Hesperetin Against Lipopolysaccharide-induced Acute Renal Injury in Rat
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
10953.pdf
Boyut:
1.18 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Sağlık Yüksekokulu Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu