Mitochondrial DNA common deletion is not associated with thyroid, breast and colorectal tumors in Turkish patients

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dc.authorid0000-0002-1100-765X
dc.authorid0000-0002-9360-8116
dc.authorid0000-0002-1100-765X
dc.authorid0000-0002-6044-1372
dc.authorscopusid6602491471
dc.authorscopusid57195257114
dc.authorscopusid7102340078
dc.authorscopusid23988383500
dc.authorscopusid7006479102
dc.authorscopusid6602211238
dc.authorscopusid55942015600
dc.authorwosidAkkiprik, Mustafa/A-6453-2017
dc.authorwosidcelikel, cigdem/AAB-6540-2021
dc.authorwosidAkkiprik, Mustafa/AAD-6167-2020
dc.contributor.authorAral, Cenk
dc.contributor.authorAkkiprik, Mustafa
dc.contributor.authorKaya, Handan
dc.contributor.authorAtaizi-Celikel, Çiğdem
dc.contributor.authorÇaglayan, Sinan
dc.contributor.authorÖzışık, Gökhan
dc.contributor.authorÖzer, Ayşe
dc.date.accessioned2022-05-11T14:28:25Z
dc.date.available2022-05-11T14:28:25Z
dc.date.issued2010
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractRecently, efforts have been focused on mitochondrial DNA changes and their relation to human cancers. Among them, a 4977 bp deletion of mitochondrial DNA, named common deletion, has been investigated in several types of tumors, with inconsistent results. In this study, we investigated the presence of the common deletion in tissues from 25 breast, 25 colorectal and 50 thyroid tumors and in the adjacent healthy tissues from Turkish patients. Samples from healthy volunteers were also evaluated for comparison. Two PCR-based methods were used for the detection of the common deletion. First, two pairs of primers were used to amplify wild-type and deleted mtDNA. Then, a highly sensitive nested-PCR was performed, to determine low amounts of deleted genomes. By the first method, wild-type mtDNAs were observed in all samples, but a deletion was observed in only six thyroid samples, by using the nested-PCR method. In conclusion, the mitochondrial common deletion was very rare in our study group and did not appear to be not related with cancer.
dc.identifier.doi10.1590/S1415-47572009005000102
dc.identifier.endpage4
dc.identifier.issn1415-4757
dc.identifier.issue1en_US
dc.identifier.pmid21637595
dc.identifier.scopus2-s2.0-77749240487
dc.identifier.scopusqualityQ3
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1590/S1415-47572009005000102
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6818
dc.identifier.volume33
dc.identifier.wosWOS:000275106000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAral, Cenk
dc.institutionauthorDemirkesen, Seyma
dc.institutionauthorBircan, Rifat
dc.institutionauthorYasar Şirin, Duygu
dc.language.isoen
dc.publisherSoc Brasil Genetica
dc.relation.ispartofGenetics and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectmitochondrial DNA
dc.subjectcommon deletion
dc.subjectcancer
dc.subjectSomatic Mutations
dc.subjectCancer
dc.subjectDiseases
dc.subjectGenome
dc.titleMitochondrial DNA common deletion is not associated with thyroid, breast and colorectal tumors in Turkish patients
dc.typeArticle

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