Glutathione (GSH) Determination by a Very Simple Electrochemical Method

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dc.authorscopusid6506764918
dc.authorscopusid6603789064
dc.authorwosidMENGÜLLÜOĞLU, UMUT/AAG-7084-2021
dc.authorwosidSezgintürk, Mustafa Kemal/AAY-1439-2021
dc.authorwosidDİNÇKAYA, ERHAN/AAG-7096-2021
dc.contributor.authorSezgintürk, Mustafa Kemal
dc.contributor.authorDinçkaya, Erhan
dc.date.accessioned2022-05-11T14:29:45Z
dc.date.available2022-05-11T14:29:45Z
dc.date.issued2011
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractGlutathione (GSH; gamma-glutamylcysteinylglycine) is ubiquitous in mammalian and other living cells. It contains an unusual peptide linkage between the amine group of cysteine and the carboxyl group of the glutamate side chain. It has several important functions, including protection against oxidative stress. It is synthesized from its constituent amino acids by the consecutive actions of gamma-glutamylcysteine synthetase and GSH synthetase. Cellular levels of GSH may be increased by supplying substrates and GSH delivery compounds. Increasing cellular GSH may be therapeutically useful. In this study, we investigated the applicability of the glassy carbon electrode coated with thin Hg film layer to the determination of reduced glutathione (GSH). For this purpose, firstly, Hg coating process parameters were studied such as concentration of mercury coating solution, coating current, coating temperature. Then, working conditions were investigated. At the end of these studies, we concluded that although some of limitations, the sensor would be applicable to the determination of reduced glutathione.
dc.identifier.doi10.1007/s10989-011-9243-2
dc.identifier.endpage92
dc.identifier.issn1573-3149
dc.identifier.issn1573-3904
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-80052708165
dc.identifier.scopusqualityQ3
dc.identifier.startpage87
dc.identifier.urihttps://doi.org/10.1007/s10989-011-9243-2
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7119
dc.identifier.volume17
dc.identifier.wosWOS:000293235700002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSezgintürk, Mustafa Kemal
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInternational Journal of Peptide Research and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGlutathione
dc.subjectThin Hg films
dc.subjectGSH
dc.subjectBiosensor
dc.subjectMercury film electrode
dc.subjectPerformance Liquid-Chromatography
dc.subjectStripping Voltammetry
dc.subjectRedox Derivatization
dc.subjectGene-Expression
dc.subjectIn-Vivo
dc.subjectDisulfide
dc.subjectSpectroscopy
dc.subjectThiols
dc.subjectLiver
dc.titleGlutathione (GSH) Determination by a Very Simple Electrochemical Method
dc.typeArticle

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