Synthesis, characterization and biological evaluation of novel antimony(III) iodide complexes with tetramethylthiourea and N-ethylthiourea

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dc.authorscopusid36785856200
dc.authorscopusid57192317122
dc.authorscopusid35363944400
dc.authorscopusid8235840100
dc.authorscopusid46860923200
dc.authorscopusid6602925165
dc.authorscopusid14525091600
dc.contributor.authorÖztürk, İbrahim İsmet
dc.contributor.authorYarar, S.
dc.contributor.authorGürgan, Muazzez
dc.contributor.authorCeyhan, Deniz
dc.contributor.authorBanti, Christina N.
dc.contributor.authorHadjikakou, Sotiris K.
dc.contributor.authorTasiopoulos, Anastasios J.
dc.date.accessioned2022-05-11T14:02:46Z
dc.date.available2022-05-11T14:02:46Z
dc.date.issued2019
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractNovel trivalent antimony(III) complexes with tetramethylthiourea (TMTU) and N-ethylthiourea (NETU) were synthesized by the reaction of antimony(III) iodide (SbI3). Antimony(III) iodide complexes of formulae {[SbI2(µ2-I)(TMTU)2]2} (1) and {[(NETU)SbI2(µ2-I)2(µ2-S-NETU)SbI2(NETU)]} (2) were characterized by spectroscopic techniques (FT-IR, FT-Raman, 1H and 13C NMR), TG-DTA analysis and X-ray diffraction (XRD) analysis. Single-crystal X-ray diffraction studies showed that the complexes existed as doubly bridged (1) and triply bridged (2) dimers. Crystal structure of the ligand N-ethylthiourea was also determined with single crystal X-ray diffraction analysis. Complexes 1 and 2 were evaluated for their in vitro cytotoxic activity against human adenocarcinoma cells HeLa (cervix). The toxicity of 1 and 2 was evaluated on normal human fetal lung fibroblast cells (MRC-5). Both complexes showed selectivity against the cancerous, than normal cells. The influence of 1 and 2, on the catalytic peroxidation of the linoleic acid by the enzyme lipoxygenase (LOX) was determined experimentally and theoretically. The complexes 1 and 2 exhibited higher activity than free ligands against LOX. The in vitro antibacterial activities of free ligands and their antimony(III) iodide complexes 1 and 2 were tested against two Gram-negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853) and two Gram-positive (Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212) bacteria. The complexes 1 and 2 were much more effective in terms of antimicrobial activity compared to the free ligands. © 2019 Elsevier B.V.
dc.description.sponsorshipI.I.O. acknowledges the financial support from Tekirdag Namik Kemal University Scientific Research Project (Project No. NKUBAP.01.GA.16.014).
dc.identifier.doi10.1016/j.ica.2019.03.020
dc.identifier.endpage24
dc.identifier.issn0020-1693
dc.identifier.scopus2-s2.0-85063399125
dc.identifier.scopusqualityQ2
dc.identifier.startpage14
dc.identifier.urihttps://doi.org/10.1016/j.ica.2019.03.020
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4478
dc.identifier.volume491
dc.identifier.wosWOS:000465562900003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖztürk, İbrahim İsmet
dc.institutionauthorYarar, S.
dc.institutionauthorGürgan, Muazzez
dc.institutionauthorCeyhan, Deniz
dc.language.isoen
dc.publisherElsevier S.A.
dc.relation.ispartofInorganica Chimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntimicrobial
dc.subjectAntimony(III) complexes
dc.subjectCytotoxicity
dc.subjectLipoxygenase
dc.subjectMolecular docking
dc.subjectThioureas
dc.subjectCell culture
dc.subjectCrystal structure
dc.subjectCytotoxicity
dc.subjectDimers
dc.subjectEscherichia coli
dc.subjectLanthanum compounds
dc.subjectLigands
dc.subjectLinoleic acid
dc.subjectSingle crystals
dc.subjectSpectroscopic analysis
dc.subjectStaphylococcus aureus
dc.subjectSynthesis (chemical)
dc.subjectThioureas
dc.subjectX ray powder diffraction
dc.subjectAntimicrobial
dc.subjectAntimony(III)
dc.subjectHuman fetal lung fibroblast
dc.subjectLipoxygenases
dc.subjectMolecular docking
dc.subjectSingle crystal X-ray diffraction analysis
dc.subjectSingle-crystal X-ray diffraction studies
dc.subjectSpectroscopic technique
dc.subjectAntimony compounds
dc.titleSynthesis, characterization and biological evaluation of novel antimony(III) iodide complexes with tetramethylthiourea and N-ethylthiourea
dc.typeArticle

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