Prognostic Role of Lymphovascular Invasion and Perineural Invasion in Breast Cancer Treated with Neoadjuvant Chemotherapy

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dc.authoridCavdar, Eyyup/0000-0001-5885-3047
dc.authorscopusid57226624079
dc.authorscopusid57226431644
dc.authorscopusid57431169800
dc.authorscopusid56082620300
dc.authorscopusid15844109600
dc.authorscopusid57218822513
dc.contributor.authorÇavdar, Eyyüp
dc.contributor.authorİriağaç, Yakup
dc.contributor.authorKaraboyun, Kubilay
dc.contributor.authorAvcı, Okan
dc.contributor.authorÖznur, Meltem
dc.contributor.authorŞeber, Erdoğan Selçuk
dc.date.accessioned2023-04-20T08:02:26Z
dc.date.available2023-04-20T08:02:26Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractIn our study, we investigated the predictive properties of LVI (lymphovascular invasion) and PNI (perineural invasion) on survival times from pathology specimens obtained from surgical operation after neoadjuvant chemotherapy (NAC) with breast cancer patients. Two hundered eleven female patients were included in this study. We evaluated the relationship between potential prognostic factors and mean recurrence-free survival (RFS) and overall survival (OS) times using Kaplan-Meier methodology and Cox proportional hazard modelling.The mean follow-up time was 27.3 months.PNI positive patients had shorter RFS and OS times than PNI negatives (p< 0.001, p= 0.002, respectively), and LVI positive patients had shorter RFS and OS times than LVI negatives (p< 0.001, p< 0.001, re-spectively). In the multivariate analysis performed, the presence of pN stage and PNI were found to be predictive for RFS (p= 0.047, p< 0.001, respectively), while pT stage and PNI positivity were found to be predictive for OS (p= 0.035, p= 0.017, respectively). LVI did not show the property of being an independent predictive marker for survival. PNI caused significant survival differences in all subtypes for both RFS (log-rank p< 0.001, p= 0.003, p= 0.001, respectively) and OS(log-rank p= 0.035, p= 0.006, p= 0.020 respectively) in HR+/Her2-, Her2+ and Triple negative breast cancer subtyping. LVI, on the other hand, caused survival distribution difference for RFS (p= 0.021) in the HR+/Her2-subtype and for both RFS and OS in the Triple-negative subtype (p< 0.001, p= 0.025, respectively). PNI is strongly and significantly associated with RFS and OS. We suggest that it can be used in identifying high-risk patients for recurrence of PNI and in new staging systems.
dc.identifier.doi10.4999/uhod.226300
dc.identifier.endpage149
dc.identifier.issn1306-133X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85134042941
dc.identifier.scopusqualityQ4
dc.identifier.startpage141
dc.identifier.trdizinid1179057
dc.identifier.urihttps://doi.org/10.4999/uhod.226300
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10921
dc.identifier.volume32
dc.identifier.wosWOS:000824359700002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorÇavdar, Eyyüp
dc.institutionauthorİriağaç, Yakup
dc.institutionauthorKaraboyun, Kubilay
dc.institutionauthorAvcı, Okan
dc.institutionauthorÖznur, Meltem
dc.institutionauthorŞeber, Erdoğan Selçuk
dc.language.isoen
dc.publisherAkad Doktorlar Yayinevi
dc.relation.ispartofUhod-Uluslararasi Hematoloji-Onkoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLymphovascular
dc.subjectPerineural
dc.subjectNeoadjuvant
dc.subjectBreast Cancer
dc.subjectPrognostic
dc.subjectSurgical Adjuvant Breast
dc.subjectSurvival
dc.subjectRecommendations
dc.subjectRecurrence
dc.subjectTherapy
dc.subjectDisease
dc.subjectRisk
dc.titlePrognostic Role of Lymphovascular Invasion and Perineural Invasion in Breast Cancer Treated with Neoadjuvant Chemotherapy
dc.typeArticle

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