Comparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rats

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dc.authorid0000-0002-0103-5868
dc.authorscopusid57297089700
dc.authorscopusid57296022200
dc.authorscopusid6602521213
dc.authorscopusid57196002965
dc.authorwosidKilic, Servet/ABA-3409-2020
dc.authorwosidHatipoglu, Fatih/M-8076-2014
dc.contributor.authorErkal, Tuba Ozge Yasar
dc.contributor.authorKılıç, Servet
dc.contributor.authorHatipoğlu, Fatih
dc.contributor.authorTerzi, Funda
dc.date.accessioned2022-05-11T14:42:13Z
dc.date.available2022-05-11T14:42:13Z
dc.date.issued2019
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Bilimler Bölümü, Cerrahi Ana Bilim Dalı
dc.description.abstractClinical effects and pathological changes of synthetic oligodeoxynucleotide (ODN), prednol (PRD) and azathioprine (AZA) was compared on uveitis treatment in rats. A total of 28 Wistar Albino, female, adult rats were divided into Control (C), PRD, AZA and ODN groups. Uveitis was induced by 176 mu g/rat subcutan injection E. coli, LPS and observed in all animals after 48 hours. Then, 0.25 mg/rat/day AZA and 1.25 mg/rat/day of methylprenidolone was administered by gavage in AZA and PRD groups for ten days. In the ODN group, 178 mu g/rat ODN was administered IP totally four times. A numerical weight loss was seen in all groups in the course of the infection period, but dropped dramatically in the PRD group during the treatment period. Average value of right and left eye results showed that immunesuppressive effect of Prednol was higher in terms of IOP values compared to others whereas Shirmer test values were the lowest in the post-treatment period. Finally, Prednol was more effective with its immunesuppressive effect resulting in recovery of photophobia, vascularization and oedema in iris vessels.
dc.description.sponsorshipScientific Projects Research Commision of Namik Kemal University [NKUBAP.10, 16.019]
dc.description.sponsorshipThis study was supported by the Scientific Projects Research Commision of Namik Kemal University (Project no: NKUBAP.10.GA.16.019).
dc.identifier.doi10.18805/ijar.B-924
dc.identifier.endpage831
dc.identifier.issn0367-6722
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85117124323
dc.identifier.scopusqualityQ2
dc.identifier.startpage827
dc.identifier.urihttps://doi.org/10.18805/ijar.B-924
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9290
dc.identifier.volume53
dc.identifier.wosWOS:000472915800023
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorErkal, Tuba Ozge Yasar
dc.institutionauthorKılıç, Servet
dc.language.isoen
dc.publisherAgricultural Research Communication Centre
dc.relation.ispartofIndian Journal of Animal Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAzathioprine
dc.subjectODN
dc.subjectPrednol
dc.subjectRat
dc.subjectUveitis
dc.subjectPrevention
dc.subjectModels
dc.titleComparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rats
dc.typeArticle

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