The effects of allium sativum on immunity within the scope of COVID-19 infection

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dc.authorscopusid6601976056
dc.authorscopusid6602805712
dc.contributor.authorDonma, Mustafa Metin
dc.contributor.authorDonma, Orkide
dc.date.accessioned2022-05-11T14:05:00Z
dc.date.available2022-05-11T14:05:00Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractThe severity of coronavirus disease 2019 (COVID?19) infection is quite variable and the manifestations varies from asymptomatic disease to severe acute respiratory infection. Fever, dry cough, dyspnea, myalgia, fatigue, loss of appetite, olfactory and gustatory dysfunctions are the most prevalent general symptoms. Decreased immune system cells such as suppressed regulatory T cells, cytotoxic and helper T cells, natural killer cells, monocytes/macrophages and increased proinflammatory cytokines are the characteristic features. Compounds derived from Allium sativum (garlic) have the potential to decrease the expression of proinflammatory cytokines and to reverse the immunological abnormalities to more acceptable levels. Allium sativum is suggested as a beneficial preventive measure before being infected with SARS?CoV?2 virus. Allium sativum is a functional food well-known for its immunomodulatory, antimicrobial, antiinflammatory, antimutagenic, antitumor properties. Its antiviral efficiency was also demonstrated. Some constituents of this plant were found to be active against protozoan parasites. Within this context, it appears to reverse most immune system dysfunctions observed in patients with COVID-19 infection. The relations among immune system parameters, leptin, leptin receptor, adenosin mono phosphate-activated protein kinase, peroxisome proliferator activated receptor-gamma have also been interpreted. Leptin's role in boosting proinflammatory cytokines and in appetite decreasing suggest the possible beneficial effect of decreasing the concentration of this proinflammatory adipose tissue hormone in relieving some symptoms detected during COVID-19 infection. In conclusion, Allium sativum may be an acceptable preventive measure against COVID-19 infection to boost immune system cells and to repress the production and secretion of proinflammatory cytokines as well as an adipose tissue derived hormone leptin having the proinflammatory nature. © 2020 Elsevier Ltd
dc.identifier.doi10.1016/j.mehy.2020.109934
dc.identifier.issn0306-9877
dc.identifier.pmid32512493
dc.identifier.scopus2-s2.0-85085770410
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2020.109934
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4860
dc.identifier.volume144
dc.identifier.wosWOS:000669488400071
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDonma, Mustafa Metin
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.ispartofMedical Hypotheses
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAllium sativum
dc.subjectCovid-19 infection
dc.subjectGarlic
dc.subjectLeptin
dc.subjectNatural killer cells
dc.subjectT lymphocytes
dc.subjectadenosine phosphate
dc.subjectagouti related protein
dc.subjectC reactive protein
dc.subjectgamma interferon
dc.subjecthydroxymethylglutaryl coenzyme A reductase kinase
dc.subjectinterleukin 1
dc.subjectinterleukin 6
dc.subjectleptin
dc.subjectleptin receptor
dc.subjectperoxisome proliferator activated receptor gamma
dc.subjectprotein kinase
dc.subjectresistin
dc.subjecttumor necrosis factor
dc.subjectLEP protein, human
dc.subjectleptin
dc.subjectArticle
dc.subjectCD4+ T lymphocyte
dc.subjectCD8+ T lymphocyte
dc.subjectcell expansion
dc.subjectcell infiltration
dc.subjectcellular immunity
dc.subjectclinical effectiveness
dc.subjectcoronavirus disease 2019
dc.subjectdisease severity
dc.subjectfatty acid oxidation
dc.subjectgarlic
dc.subjectgene expression
dc.subjecthelper cell
dc.subjecthuman
dc.subjectimmunity
dc.subjectmorbidity
dc.subjectmortality risk
dc.subjectnatural killer cell
dc.subjectregulatory T lymphocyte
dc.subjectrisk factor
dc.subjectT lymphocyte
dc.subjectTh1 cell
dc.subjectbiological model
dc.subjectfunctional food
dc.subjectgarlic
dc.subjectimmunology
dc.subjectvirology
dc.subjectCOVID-19
dc.subjectFunctional Food
dc.subjectGarlic
dc.subjectHost Microbial Interactions
dc.subjectHumans
dc.subjectLeptin
dc.subjectModels, Immunological
dc.subjectSARS-CoV-2
dc.subjectT-Lymphocytes
dc.titleThe effects of allium sativum on immunity within the scope of COVID-19 infection
dc.typeArticle

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