The effects of allium sativum on immunity within the scope of COVID-19 infection
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Dosyalar
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Churchill Livingstone
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The severity of coronavirus disease 2019 (COVID?19) infection is quite variable and the manifestations varies from asymptomatic disease to severe acute respiratory infection. Fever, dry cough, dyspnea, myalgia, fatigue, loss of appetite, olfactory and gustatory dysfunctions are the most prevalent general symptoms. Decreased immune system cells such as suppressed regulatory T cells, cytotoxic and helper T cells, natural killer cells, monocytes/macrophages and increased proinflammatory cytokines are the characteristic features. Compounds derived from Allium sativum (garlic) have the potential to decrease the expression of proinflammatory cytokines and to reverse the immunological abnormalities to more acceptable levels. Allium sativum is suggested as a beneficial preventive measure before being infected with SARS?CoV?2 virus. Allium sativum is a functional food well-known for its immunomodulatory, antimicrobial, antiinflammatory, antimutagenic, antitumor properties. Its antiviral efficiency was also demonstrated. Some constituents of this plant were found to be active against protozoan parasites. Within this context, it appears to reverse most immune system dysfunctions observed in patients with COVID-19 infection. The relations among immune system parameters, leptin, leptin receptor, adenosin mono phosphate-activated protein kinase, peroxisome proliferator activated receptor-gamma have also been interpreted. Leptin's role in boosting proinflammatory cytokines and in appetite decreasing suggest the possible beneficial effect of decreasing the concentration of this proinflammatory adipose tissue hormone in relieving some symptoms detected during COVID-19 infection. In conclusion, Allium sativum may be an acceptable preventive measure against COVID-19 infection to boost immune system cells and to repress the production and secretion of proinflammatory cytokines as well as an adipose tissue derived hormone leptin having the proinflammatory nature. © 2020 Elsevier Ltd
Açıklama
Anahtar Kelimeler
Allium sativum, Covid-19 infection, Garlic, Leptin, Natural killer cells, T lymphocytes, adenosine phosphate, agouti related protein, C reactive protein, gamma interferon, hydroxymethylglutaryl coenzyme A reductase kinase, interleukin 1, interleukin 6, leptin, leptin receptor, peroxisome proliferator activated receptor gamma, protein kinase, resistin, tumor necrosis factor, LEP protein, human, leptin, Article, CD4+ T lymphocyte, CD8+ T lymphocyte, cell expansion, cell infiltration, cellular immunity, clinical effectiveness, coronavirus disease 2019, disease severity, fatty acid oxidation, garlic, gene expression, helper cell, human, immunity, morbidity, mortality risk, natural killer cell, regulatory T lymphocyte, risk factor, T lymphocyte, Th1 cell, biological model, functional food, garlic, immunology, virology, COVID-19, Functional Food, Garlic, Host Microbial Interactions, Humans, Leptin, Models, Immunological, SARS-CoV-2, T-Lymphocytes
Kaynak
Medical Hypotheses
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
144
