MTHFR, prothrombin and Factor V gene variants in Turkish patients with coronary artery stenosis

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dc.authorid0000-0001-5291-8620
dc.authorscopusid57125854800
dc.authorscopusid8416126500
dc.authorscopusid6507338922
dc.authorscopusid8575324900
dc.authorscopusid36808522500
dc.authorscopusid56023207300
dc.authorwosidBircan, Rıfat/A-7344-2018
dc.contributor.authorCaner, Müge
dc.contributor.authorBircan, Rifat
dc.contributor.authorSevinc, Deniz
dc.contributor.authorBenli, Fehime
dc.contributor.authorGuney, A. Ilter
dc.contributor.authorKurtoglu, Nuri
dc.date.accessioned2022-05-11T14:28:23Z
dc.date.available2022-05-11T14:28:23Z
dc.date.issued2008
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractMany epidemiological studies have reported an association between hemostatic factors and risk of both coronary and peripheral artery diseases. Using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis, we investigated the association between coronary artery disease and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), prothrombin (G20210A), and factor V (A4070G) genes. We screened these gene variants in 174 subjects who had undergone coronary angiography - 115 patients with patent coronary artery disease (grade 3 vessel disease, i.e., significant coronary stenosis), and 59 healthy controls with grade 0 vessel disease. The analysis of our data did not show any statistically significant association between coronary artery disease (CAD) and the investigated polymorphisms.
dc.identifier.doi10.1590/S1415-47572008005000023
dc.identifier.endpage838
dc.identifier.issn1415-4757
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-62549138704
dc.identifier.scopusqualityQ3
dc.identifier.startpage836
dc.identifier.urihttps://doi.org/10.1590/S1415-47572008005000023
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6806
dc.identifier.volume31
dc.identifier.wosWOS:000261856700006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBircan, Rifat
dc.language.isoen
dc.publisherSoc Brasil Genetica
dc.relation.ispartofGenetics and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectgenetic polymorphism
dc.subjectcoronary disease
dc.subjectMTHFR gene
dc.subjectprothrombin gene
dc.subjectFactor V gene
dc.subjectMethylenetetrahydrofolate Reductase Gene
dc.subjectVenous Thrombosis
dc.subjectCommon Mutation
dc.subjectRisk-Factors
dc.subjectDisease
dc.titleMTHFR, prothrombin and Factor V gene variants in Turkish patients with coronary artery stenosis
dc.typeArticle

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