Role of circulating microRNAs in acute appendicitis

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dc.authorid0000-0002-3041-7427
dc.authorid0000-0003-1604-9565
dc.authorscopusid57220668797
dc.authorscopusid56152961400
dc.authorscopusid56223656900
dc.authorscopusid24725733300
dc.authorscopusid57202338026
dc.authorscopusid57202336504
dc.authorscopusid57202339179
dc.authorwosidGünay, Nahide Ekici/L-1692-2019
dc.authorwosidGünay, Nurullah/B-6853-2019
dc.authorwosidSener, Elif Funda/AAL-8916-2021
dc.authorwosidTaheri, Serpil/AAL-8870-2021
dc.contributor.authorSeyhan, Avni Uygar
dc.contributor.authorŞener, Elif Funda
dc.contributor.authorBol, Oğuzhan
dc.contributor.authorTaheri, Serpil
dc.contributor.authorTopaloğlu, Tuğba
dc.contributor.authorTufan, Esra
dc.contributor.authorGünay, Nurullah
dc.date.accessioned2022-05-11T14:37:01Z
dc.date.available2022-05-11T14:37:01Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalı
dc.description.abstractBACKGROUND: Acute appendicitis (AA) is a momentous, emergency, surgical pathology that has still been investigated for both etiopathogenetic unknowns and challenges in diagnosis. Presently, there is little information about the role of microRNAs (miRNAs), which have basic biological functions in the cell, can be a marker, and are associated with various pathologies, in patients with AA. The aim of this study was to investigate the expressions of some miRNAs in AA. METHODS: Overall, 41 miRNAs were screened in 48 individuals comprising 24 patients with AA and 24 healthy controls at Erciyes University Genome and Stem Cell Center (GENKOK). The obtained data were analyzed using appropriate statistical methods. RESULTS: miR-29c-3p was found to be increased 2-fold during the first 4-6 h in AA, and this increase was revealed to be statistically significant compared with healthy individuals. Similarly, expressions of let-7b-5p, let-7i-5p, miR-30a-5p, miR-29b-3p, and miR-23a-3p also increased approximately 2-fold in AA, although not statistically significant. No significant differences were found in the screening of the remaining 35 miRNAs in patients with AA. CONCLUSION: Although there is little information about the relationship between AA and miRNAs currently, miR-29c-3p was reported to increase in the acute period of AA in this study. With the current results, it can be argued that miR-29c-3p bears the potential to be a marker in patients with AA. The present study may also be a basic research for more extensive and necessary miRNAs screening in this field.
dc.description.sponsorshipScientific Research Projects Department of Erciyes University, Kayseri [TTU-2016-6072]
dc.description.sponsorshipThis study was supported by a project (TTU-2016-6072) from the Scientific Research Projects Department of Erciyes University, Kayseri.
dc.identifier.doi10.5505/tjtes.2017.22379
dc.identifier.endpage215
dc.identifier.issn1306-696X
dc.identifier.issue3en_US
dc.identifier.pmid29786815
dc.identifier.scopus2-s2.0-85047958745
dc.identifier.scopusqualityQ2
dc.identifier.startpage211
dc.identifier.urihttps://doi.org/10.5505/tjtes.2017.22379
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8534
dc.identifier.volume24
dc.identifier.wosWOS:000432984700005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBol, Oğuzhan
dc.language.isoen
dc.publisherTurkish Assoc Trauma Emergency Surgery
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcute appendicitis
dc.subjectinflammation
dc.subjectmicroRNAs
dc.subjectCancer
dc.subjectRnas
dc.titleRole of circulating microRNAs in acute appendicitis
dc.title.alternativeAkut apandisitte dolaşımdaki mikroRNA'lar]
dc.typeArticle

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