Predictive value of noninvasive indices in chronic hepatitis B virus-related fibrosis

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dc.authorscopusid15844109600
dc.authorscopusid37058172000
dc.authorscopusid57218879837
dc.contributor.authorÖznur, Meltem
dc.contributor.authorTopçu, Birol
dc.contributor.authorÇelikkol, Aliye
dc.date.accessioned2022-05-11T14:02:44Z
dc.date.available2022-05-11T14:02:44Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjectives Despite being an invasive method, liver biopsy followed by pathological grading remains the gold standard in evaluating liver fibrosis resulting from chronic hepatitis B virus (HBV) infection. The present study aims to evaluate the utility of biochemical parameters and their derived indices in predicting development of fibrosis related to HBV infection. Patients and methods Pathology results and biochemical parameters of patients who underwent liver biopsy were retrieved from electronic archive records dated 2010-2019 and evaluated retrospectively. Pathological fibrosis grading was performed as per Ishak scoring, with scores of 1-2 considered as mild fibrosis and 3-6 as advanced fibrosis. Results The mean age of 302 patients was 37.69 ± 11.33 years. Of the 302 patients, 230 (76.2%) had mild fibrosis and 72 (23.8%) had advanced fibrosis. Age-platelet index, aspartate aminotransferase/platelet ratio index, fibrosis-4 (FIB-4), modified fibrosis-4, platelets count, aspartate aminotransferase to alanine aminotransferase ratio/platelet ratio index, Goteborg University Cirrhosis Index and King's score were markedly and significantly higher in patients with advanced fibrosis than those with mild fibrosis. FIB-4, age-platelet index and King's score had higher (>80%) area under the curve values than other indices in the receiver operating characteristics analysis. Evaluation of sensitivity, specificity and accuracy of these indices with the specified cut-off values revealed 87% sensitivity with FIB-4, 70% specificity with King's score and 72% accuracy with the age-platelet index. Conclusion In this study, the highest rates of sensitivity, specificity and accuracy in distinguishing and predicting liver fibrosis were observed with the noninvasive indices FIB-4, King's score and the age-platelet index, respectively. © 2021 Lippincott Williams and Wilkins. All rights reserved.
dc.identifier.doi10.1097/MEG.0000000000002045
dc.identifier.endpage582
dc.identifier.issn0954-691X
dc.identifier.pmid33657603
dc.identifier.scopus2-s2.0-85102482199
dc.identifier.scopusqualityQ2
dc.identifier.startpage577
dc.identifier.urihttps://doi.org/10.1097/MEG.0000000000002045
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4458
dc.identifier.wosWOS:000639297500018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖznur, Meltem
dc.institutionauthorTopçu, Birol
dc.institutionauthorÇelikkol, Aliye
dc.language.isoen
dc.publisherLippincott Williams and Wilkins
dc.relation.ispartofEuropean Journal of Gastroenterology and Hepatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectchronic hepatitis B
dc.subjectfibrosis
dc.subjectnoninvasive indices
dc.subjectpredictive value
dc.subjectaspartate aminotransferase
dc.subjectadult
dc.subjectbiopsy
dc.subjectchronic hepatitis B
dc.subjectcomplication
dc.subjectHepatitis B virus
dc.subjecthuman
dc.subjectliver cirrhosis
dc.subjectmiddle aged
dc.subjectplatelet count
dc.subjectpredictive value
dc.subjectreceiver operating characteristic
dc.subjectretrospective study
dc.subjectseverity of illness index
dc.subjectAdult
dc.subjectAspartate Aminotransferases
dc.subjectBiopsy
dc.subjectHepatitis B virus
dc.subjectHepatitis B, Chronic
dc.subjectHumans
dc.subjectLiver Cirrhosis
dc.subjectMiddle Aged
dc.subjectPlatelet Count
dc.subjectPredictive Value of Tests
dc.subjectRetrospective Studies
dc.subjectROC Curve
dc.subjectSeverity of Illness Index
dc.titlePredictive value of noninvasive indices in chronic hepatitis B virus-related fibrosis
dc.typeArticle

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