Predictive value of noninvasive indices in chronic hepatitis B virus-related fibrosis
Yükleniyor...
Dosyalar
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams and Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives Despite being an invasive method, liver biopsy followed by pathological grading remains the gold standard in evaluating liver fibrosis resulting from chronic hepatitis B virus (HBV) infection. The present study aims to evaluate the utility of biochemical parameters and their derived indices in predicting development of fibrosis related to HBV infection. Patients and methods Pathology results and biochemical parameters of patients who underwent liver biopsy were retrieved from electronic archive records dated 2010-2019 and evaluated retrospectively. Pathological fibrosis grading was performed as per Ishak scoring, with scores of 1-2 considered as mild fibrosis and 3-6 as advanced fibrosis. Results The mean age of 302 patients was 37.69 ± 11.33 years. Of the 302 patients, 230 (76.2%) had mild fibrosis and 72 (23.8%) had advanced fibrosis. Age-platelet index, aspartate aminotransferase/platelet ratio index, fibrosis-4 (FIB-4), modified fibrosis-4, platelets count, aspartate aminotransferase to alanine aminotransferase ratio/platelet ratio index, Goteborg University Cirrhosis Index and King's score were markedly and significantly higher in patients with advanced fibrosis than those with mild fibrosis. FIB-4, age-platelet index and King's score had higher (>80%) area under the curve values than other indices in the receiver operating characteristics analysis. Evaluation of sensitivity, specificity and accuracy of these indices with the specified cut-off values revealed 87% sensitivity with FIB-4, 70% specificity with King's score and 72% accuracy with the age-platelet index. Conclusion In this study, the highest rates of sensitivity, specificity and accuracy in distinguishing and predicting liver fibrosis were observed with the noninvasive indices FIB-4, King's score and the age-platelet index, respectively. © 2021 Lippincott Williams and Wilkins. All rights reserved.
Açıklama
Anahtar Kelimeler
chronic hepatitis B, fibrosis, noninvasive indices, predictive value, aspartate aminotransferase, adult, biopsy, chronic hepatitis B, complication, Hepatitis B virus, human, liver cirrhosis, middle aged, platelet count, predictive value, receiver operating characteristic, retrospective study, severity of illness index, Adult, Aspartate Aminotransferases, Biopsy, Hepatitis B virus, Hepatitis B, Chronic, Humans, Liver Cirrhosis, Middle Aged, Platelet Count, Predictive Value of Tests, Retrospective Studies, ROC Curve, Severity of Illness Index
Kaynak
European Journal of Gastroenterology and Hepatology
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
