Development and Validation of Confirmatory Method for Analysis of Nitrofuran Metabolites in Milk, Honey, Poultry Meat and Fish By Liquid Chromatography-Mass Spectrometry

Basit Öğe Kaydı
dc.authorid0000-0003-4310-2077
dc.authorscopusid57183953600
dc.authorscopusid57184308400
dc.authorscopusid56988763200
dc.authorwosidOzdemir, Nurullah/AAZ-6892-2020
dc.contributor.authorAlkan, Fatih
dc.contributor.authorKotan, Arzu
dc.contributor.authorÖzdemir, Nurullah
dc.date.accessioned2022-05-11T14:42:17Z
dc.date.available2022-05-11T14:42:17Z
dc.date.issued2016
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümü, Farmakoloji ve Toksikoloji Ana Bilim Dalı
dc.description.abstractIn this study we have devoloped and validated a confirmatory analysis method for nitrofuran metabolites, which is in accordance with European Commission Decision 2002/657/EC requirements. Nitrofuran metabolites in honey, milk, poultry meat and fish samples were acidic hydrolised followed by derivatisation with nitrobenzaldehyde and liquid-liquid extracted with ethylacetate. The quantitative and confirmative determination of nitrofuran metbolites was performed by liquid chromatography/electrospray ionisation tandem mass spectrometry (LC/ESI-MS/MS) in the positive ion mode. In-house method validation was performed and reported data of validation (specificity, linearity, recovery, CC alpha and CC beta). The advantage of this method is that it avoids the use of clean-up by Solid-Phase Extraction (SPE). Furthermore, low levels of nitrofuran metabolites are detectable and quantitatively confirmed at a rapid rate in all samples.
dc.identifier.doi10.1515/macvetrev-2015-0060
dc.identifier.endpage22
dc.identifier.issn1409-7621
dc.identifier.issn1857-7415
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84961190923
dc.identifier.scopusqualityQ3
dc.identifier.startpage15
dc.identifier.urihttps://doi.org/10.1515/macvetrev-2015-0060
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9320
dc.identifier.volume39
dc.identifier.wosWOS:000375090800002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖzdemir, Nurullah
dc.language.isoen
dc.publisherUniv Sv Kiril & Metodij Skopje, Fak Veterinarna Medicina
dc.relation.ispartofMacedonian Veterinary Review
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectfish
dc.subjecthoney
dc.subjectLC-MS/MS
dc.subjectmilk
dc.subjectnitrofuran metabolites
dc.subjectpoultry meat
dc.subjectAnimal Feeds
dc.subjectUv
dc.titleDevelopment and Validation of Confirmatory Method for Analysis of Nitrofuran Metabolites in Milk, Honey, Poultry Meat and Fish By Liquid Chromatography-Mass Spectrometry
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
9320.pdf
Boyut:
428.92 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Veteriner Fakültesi Koleksiyonu