Peripheral Blood CD34+ Cell Counts in Patients With Severe Sepsis
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Turkish Soc Immunology
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Objectives: This study aims to determine the impact of severe sepsis (SS) on CD34(+) cell counts in the peripheral blood and to compare these counts with those of healthy subjects. Patients and methods: CD34(+) cell counts in the peripheral blood were measured in 20 patients with SS (12 males, 8 females; mean age 58.6 +/- 16.3 years; range 23 to 81 years) (group 1) and 32 healthy subjects (16 males, 16 females; mean age 51.8 +/- 8.6 years; range 36 to 64 years) (group 2). Blood samples were obtained from group 1 two times on second day (D2) within the first 24-48 hours and on seventh day (D7) after diagnosis and once from group 2 on their first day of admittance. Results: In group 1, CD34(+) cell counts on D2 were lower than those on D7, but the difference was not statistically significant. Neither on D2 nor on D7 CD34(+) cell counts of group 1 were different than those in group 2. Although CD34(+) cell counts in group 1 on D7 were higher than those of group 2, the difference was not statistically significant. CD34(+) cell counts did not differ according to the presence of adrenal insufficiency (AI) or survival status. Conclusion: Overall CD34(+) cell counts of SS patients were not different from those in healthy subjects and not affected by the presence of AI or survival in the SS group.
Description
Keywords
CD34, healthy group, hematopoietic stem cell, severe sepsis, Endothelial Progenitor Cells, Stem-Cells
Journal or Series
Turkish Journal of Immunology
WoS Q Value
N/A
Scopus Q Value
Q4
Volume
4
Issue
2
