Fabrication of Electrochemical Immunosensor for Detection of Interleukin 8 Biomarker via Layer-by-layer Self-assembly Process on Cost-effective Fluorine Tin Oxide Electrode
Loading...
Files
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley and Sons Inc
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
A highly sensitive impedimetric immunosensor for the determination of interleukin 8 (IL 8) cancer biomarker was fabricated via simple fabrication process. A silane agent with isocyanate groups, 3-(triethoxysilyl)propyl isocyanate (IPTES), were utilized for binding of IL 8 antigen specific antibodies and self-assembled on the fluorine tin oxide (FTO) substrate with a standard silanization chemistry. Under optimum experimental conditions, the designed immunosensor had a wide linear detection range of 0.02–4 pg/mL, a low limit of detection of 11.9 fg/mL and a high sensitivity of 4.42 k? pg?1 mL cm?2. The designed biosensor displayed high reproducibility and repeatability, good selectivity against interference biomarkers. © 2021 Wiley-VCH GmbH
Description
Keywords
3-(triethoxysilyl)propyl isocyanate, Disposable electrode, Fluorine tin oxide, Interleukin 8
Journal or Series
Electroanalysis
WoS Q Value
Q3
Scopus Q Value
Q2
Volume
33
Issue
6
