Relationship of serum salusin beta levels with coronary slow flow

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dc.authorscopusid16315021800
dc.authorscopusid57211194682
dc.authorscopusid6505680586
dc.authorscopusid55317577700
dc.authorscopusid23968920100
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorAydın, Fatma
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorGüzel, Savaş
dc.date.accessioned2022-05-11T14:10:12Z
dc.date.available2022-05-11T14:10:12Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: The pathophysiology of coronary slow flow (CSF) has not been clarified. Salusin-beta is released predominantly from the atheroma plaques and influences the pathophysiologic processes of atherosclerosis. Therefore, this study aimed to determine serum salusin-beta levels in CSF and its correlation with CSF. Methods: The study included 39 patients with CSF, and the control group (n=42) consisted of consecutive subjects with normal coronary arteriogram. We measured salusin-beta and thrombolysis in myocardial infarction frame count (TFC). Results: Age, body mass index (BMI), systolic blood pressure, diabetes, hyperlipidemia, and smoking rates were similar (p values>0.05) in both groups. High sensitive C-reactive protein (2.80 +/- 1.2 vs. 2.21 +/- 1.2 mg/dL, p=0.011), salusin-beta [1205 (330-2092) vs. 162 (29-676), pg/ml, p<0.001], corrected TFC of left anterior descending coronary artery (29 +/- 9 vs. 19.7 +/- 3.7, p<0.001), circumflex artery TFC (25 +/- 10 vs. 15 +/- 3.2, p<0.001), right coronary artery TFC (28 +/- 7.1 vs. 13 +/- 3.3, p<0.001), and mean TFC (28 +/- 4.4 vs. 16 +/- 3.7, p<0.001) were significantly higher in the CSF group. In univariate and multivariate regression analysis, only BMI (unstandardized beta +/- SE=0.178 +/- 0.08, p=0.036) and salusin-beta levels (unstandardized beta +/- SE=0.006 +/- 0.01, p<0.001) were determined as predictors of CSF. There was a good correlation between serum salusin-beta and mean TFC values (r=0.564; p<0.001). Conclusion: There is an association between serum salusin-beta levels and CSF.
dc.description.sponsorshipNamik Kemal University Scientific Research Projects CommissionNamik Kemal University [02, YL.17.118]
dc.description.sponsorshipNamik Kemal University Scientific Research Projects Commission supported this study with project number 02.YL.17.118.
dc.identifier.doi10.14744/AnatolJCardiol.2019.43247
dc.identifier.endpage184
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue4en_US
dc.identifier.pmid31584433
dc.identifier.scopus2-s2.0-85072932511
dc.identifier.scopusqualityQ3
dc.identifier.startpage177
dc.identifier.urihttps://doi.org/10.14744/AnatolJCardiol.2019.43247
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5324
dc.identifier.volume22
dc.identifier.wosWOS:000488286400007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorAydın, Fatma
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorÖzkaramanlı Gür, Demet
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherAves
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectatherosclerosis
dc.subjectcoronary slow flow
dc.subjectsalusin-beta
dc.subjectendothelial dysfunction
dc.subjectIntima-Media Thickness
dc.subjectC-Reactive Protein
dc.subjectNf-Kappa-B
dc.subjectEndothelial Dysfunction
dc.subjectIntravascular Ultrasound
dc.subjectIn-Vivo
dc.subjectAtherosclerosis
dc.subjectInflammation
dc.subjectArteries
dc.subjectLesions
dc.titleRelationship of serum salusin beta levels with coronary slow flow
dc.typeArticle

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