Quantitative phase imaging of erythrocyte in epilepsy patients

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dc.authorscopusid16069377400
dc.authorscopusid16029234400
dc.authorscopusid57211906388
dc.authorscopusid57220069864
dc.authorscopusid57220875552
dc.authorscopusid6603478924
dc.contributor.authorÜnal, Aysun
dc.contributor.authorKoçahan, Özlem
dc.contributor.authorAltunan, Bengü
dc.contributor.authorGündoğdu, Aslı Aksoy
dc.contributor.authorUyanık, Merve
dc.contributor.authorÖzder, Serhat
dc.date.accessioned2022-05-11T14:02:47Z
dc.date.available2022-05-11T14:02:47Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Fizik Bölümü
dc.description.abstractThe present study focuses on the quantitative phase imaging of erythrocytes with the aim to compare the morphological differences between epilepsy patients under antiepileptic treatment, who have no other disease which may affect the erythrocyte morphology, and the healthy control group. The white light diffraction phase microscopy (WDPM) has been used to obtain the interferogram of the erythrocyte surfaces. The continuous wavelet transform with Paul wavelet has been chosen to calculate the surface profiles from this interferogram image. For the determination of alteration in morphology, besides WDPM, erythrocyte surfaces have been investigated by light microscope and scanning electron microscope. In this way, it has been possible to see the difference in terms of precision and implementation between the most commonly used methods with regard to the quantitative phase imaging. Erythrocytes from all the samples have been examined and displayed in both two- and three-dimensional way. We have observed that erythrocytes of patients with effective antiepileptic blood levels were more affected in morphology than healthy subjects. When we compared the erythrocyte morphological changes of patients who received monotherapy or polytherapy, no difference was observed. In conclusion, antiepileptic drugs (AEDs) cause red blood cell (RBC) morphological changes and a combined usage of WDPM with Paul wavelet and light microscopy methods are very convenient for studying the erythrocyte morphologies on multiple patients. © 2020 Wiley Periodicals LLC
dc.description.sponsorship19.230; 115F168
dc.description.sponsorshipThis work was supported by Tekirdağ Namık Kemal University Scientific Research Project Commission (NKUBAP.02.GA.19.230) and Turkish Scientific and Technical Research Council grant (115F168).
dc.identifier.doi10.1002/jemt.23676
dc.identifier.endpage1180
dc.identifier.issn1059-910X
dc.identifier.issue6en_US
dc.identifier.pmid33340178
dc.identifier.scopus2-s2.0-85097769047
dc.identifier.scopusqualityQ1
dc.identifier.startpage1172
dc.identifier.urihttps://doi.org/10.1002/jemt.23676
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4483
dc.identifier.volume84
dc.identifier.wosWOS:000600001000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÜnal, Aysun
dc.institutionauthorKoçahan, Özlem
dc.institutionauthorAltunan, Bengü
dc.institutionauthorGündoğdu, Aslı Aksoy
dc.institutionauthorUyanık, Merve
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofMicroscopy Research and Technique
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectepilepsy
dc.subjecterythrocyte morphology
dc.subjectlight microscopy
dc.subjectscanning electron microscopy
dc.subjectwhite light diffraction phase microscopy
dc.subjectanticonvulsive agent
dc.subjectepilepsy
dc.subjecterythrocyte
dc.subjecthuman
dc.subjectmicroscopy
dc.subjectscanning electron microscopy
dc.subjectAnticonvulsants
dc.subjectEpilepsy
dc.subjectErythrocytes
dc.subjectHumans
dc.subjectMicroscopy
dc.subjectMicroscopy, Electron, Scanning
dc.titleQuantitative phase imaging of erythrocyte in epilepsy patients
dc.typeArticle

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