Serum Neudesin Levels in Obese Adolescents

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dc.authoridÇELIKKOL, ALIYE/0000-0002-3799-4470
dc.authorwosidÇELIKKOL, ALIYE/ABE-2695-2020
dc.contributor.authorÇelikkol, Aliye
dc.contributor.authorBinay, Çiğdem
dc.contributor.authorAyçiçek, Özge
dc.contributor.authorGüzel, Savaş
dc.date.accessioned2023-04-20T08:00:15Z
dc.date.available2023-04-20T08:00:15Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: Advances in knowledge of neurotrophic factors are now revealing the complex control of energy homeostasis and appetite, as well as the crucial role these factors play in nervous system function. The aim of this study was to assess serum levels of neudesin in adolescents with obesity and to examine the relationship between these levels and metabolic outcomes. Methods: Adolescents, aged 10-17 years were enrolled. Subjects were divided into normal weight, obese and morbidly obese subgroups. Serum neudesin concentrations were compared between the groups. Results: In total, 88 adolescents were recruited, of whom 30 (34.1%) were normal weight, 15 (17.0%) were obese and 43 (48.9%) were morbidly obese. Neudesin levels were significantly lower in obese adolescents than in the control group (p=0.013). A correlation analysis applied to the whole study group revealed a negative correlation between serum neudesin concentration and body mass index (BMI) z scores (r=-0.40, p<0.001). Serum neudesin levels tended to increase in adolescents with metabolic syndrome, insulin resistance, dyslipidaemia, and hypertension but the differences were not significant (p=0.259, p=0.246, p=0.259, and p=0.523, respectively). Conclusion: Serum neudesin levels were significantly correlated with BMI z score in obese adolescents. Generally, serum neudesin levels were low in obese and morbidly obese adolescents and tended to increase with the appearance of metabolic disorders. Both obesity and associated metabolic disorders have multifactorial causes. Therefore, we suggest that the role of the neudesin molecule in the regulatory mechanisms of obesity and metabolic disorders should be further investigated with well-designed studies enrolling larger groups.
dc.identifier.doi10.4274/jcrpe.galenos.2021.2021.0208
dc.identifier.endpage75
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue1en_US
dc.identifier.pmid34776708
dc.identifier.scopus2-s2.0-85125682827
dc.identifier.scopusqualityQ2
dc.identifier.startpage69
dc.identifier.trdizinid515956
dc.identifier.urihttps://doi.org/10.4274/jcrpe.galenos.2021.2021.0208
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/515956
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10780
dc.identifier.volume14
dc.identifier.wosWOS:000778594700008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelikkol, Aliye
dc.institutionauthorBinay, Çiğdem
dc.institutionauthorAyçiçek, Özge
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofJournal of Clinical Research In Pediatric Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectObesity
dc.subjectNeudesin
dc.subjectInsulin Resistance
dc.subjectMetabolic Syndrome
dc.subjectChildren
dc.titleSerum Neudesin Levels in Obese Adolescents
dc.typeArticle

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