Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats

Basit Öğe Kaydı
dc.authorid0000-0002-6243-4221
dc.authorid0000-0002-6845-2279
dc.authorid0000-0002-1004-2146
dc.authorscopusid57190766109
dc.authorscopusid7801309581
dc.authorscopusid14037995800
dc.authorscopusid27367627900
dc.authorscopusid36561114600
dc.authorscopusid55897696600
dc.authorwosidAslan, Abdullah/C-9523-2016
dc.authorwosidTekeli, Ibrahim Ozan/W-3685-2017
dc.contributor.authorTekeli, İbrahim Özan
dc.contributor.authorAteşşahin, Ahmet
dc.contributor.authorSakin, Fatih
dc.contributor.authorAslan, Abdullah
dc.contributor.authorÇeribaşı, Songül
dc.contributor.authorYipel, Mustafa
dc.date.accessioned2022-05-11T14:42:18Z
dc.date.available2022-05-11T14:42:18Z
dc.date.issued2019
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümü, Farmakoloji ve Toksikoloji Ana Bilim Dalı
dc.description.abstractObjectiveTo compare the potential protective effects of conventional and colon-targeted lycopene (TLC) and linalool (TLN) on acetic acid (AA)-induced ulcerative colitis (UC) in rats.MethodsConventional and colon-targeted LC (10mg/kg) and LN (200mg/kg) were administered in vivo orally for 7days and sulfasalazine (100mg/kg) was also used as reference drug. Then, 4% AA was administered intrarectally to induce UC. Subsequently, the colon tissues were taken as samples for biochemical and histopathological analysis.ResultsMalondialdehyde (MDA), interleukin 1 (IL-1), IL-6, cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-B) levels were decreased (p<0.05) in the targeted groups compared to the AA group, whereas nuclear factor-erythroid 2-related factor 2 (Nrf-2) level was increased (p<0.05). Tumor necrosis factor (TNF-) level was also decreased (p<0.05) and catalase activity (CAT) was increased (p<0.05) in the TLC group compared to the AA group. IL-1 and IL-6 levels were lower in the TLC group compared to the conventional LC and sulfasalazine groups (p<0.05). COX-2 and NF-B levels were lower, while the Nrf-2 level was higher in the targeted groups compared to the conventional groups (p<0.05). Furthermore, COX-2 level was lower and Nrf-2 level was higher in the targeted groups compared to the sulfasalazine group (p<0.05).ConclusionAs expected, sulfasalazine was effective on all parameters analyzed, but the colon-targeted pretreatments were more effective from sulfasalazine on some parameters. Therefore, colon-targeted plant-derived therapies might be alternative approaches to provide protection against UC, which deserves to be investigated further.
dc.description.sponsorshipScientific Research Projects Coordination of Mustafa Kemal University [14025]
dc.description.sponsorshipThis work was financially supported by Scientific Research Projects Coordination of Mustafa Kemal University (project number: 14025).
dc.identifier.doi10.1007/s10787-018-0485-x
dc.identifier.endpage322
dc.identifier.issn0925-4692
dc.identifier.issn1568-5608
dc.identifier.issue2en_US
dc.identifier.pmid29736689
dc.identifier.scopus2-s2.0-85046531925
dc.identifier.scopusqualityQ1
dc.identifier.startpage313
dc.identifier.urihttps://doi.org/10.1007/s10787-018-0485-x
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9327
dc.identifier.volume27
dc.identifier.wosWOS:000465595000010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYipel, Mustafa
dc.language.isoen
dc.publisherSpringer Basel Ag
dc.relation.ispartofInflammopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectUlcerative colitis
dc.subjectColon targeting
dc.subjectLycopene
dc.subjectLinalool
dc.subjectRat
dc.subjectNf-Kappa-B
dc.subjectInflammatory-Bowel-Disease
dc.subjectOxidative Stress
dc.subject5-Aminosalicylic Acid
dc.subjectColorectal-Cancer
dc.subjectSuccinyl-Chitosan
dc.subjectCox-2 Expression
dc.subjectIn-Vivo
dc.subjectActivation
dc.subjectDelivery
dc.titleProtective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
9327.pdf
Boyut:
1.48 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Veteriner Fakültesi Koleksiyonu