Association of coronary artery disease severity and disulphide/native thiol ratio

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dc.authorid0000-0002-2996-3236
dc.authorscopusid57200105522
dc.authorscopusid26532378600
dc.authorscopusid7102765266
dc.authorscopusid55317577700
dc.authorscopusid55810763400
dc.authorscopusid55892061800
dc.authorscopusid16315021800
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.authorwosidBilir, Bülent/AAK-5656-2021
dc.authorwosidEREL, Ozcan/U-1008-2019
dc.contributor.authorBilir, Bülent
dc.contributor.authorAkkoyun, Dursun Çayan
dc.contributor.authorAydın, Murat
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorDeğirmenci, Hasan
dc.contributor.authorAlbayrak, Neslihan
dc.contributor.authorErel, Özcan
dc.date.accessioned2022-05-11T14:10:15Z
dc.date.available2022-05-11T14:10:15Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: Oxidative stress is among the major components of cardiovascular disease pathogenesis. Thiols play a significant role in prevention of oxidative stress in the cell. The purpose of this study is to investigate the relationship between the severity of coronary artery disease and disulphide/native thiol ratio, also determine if this ratio can be used as a marker of oxidative stress in this population. Methods: A total number of 107 patients with angiographically established coronary artery disease and 26 control subjects with normal coronary arteries were enrolled. The mean Gensini score of patients were calculated (mean=30) and a score of 29 or below was considered as mild and a score of 30 or higher coronary artery disease as severe. Serum total, native thiol was measured and the disulphide and disulphide/native thiol ratio were calculated as described by Erel&Neselioglu. Results: Patients with mild and severe coronary artery disease had significantly lower native thiol levels and higher disulphide/native thiol ratio levels when compared to the control subjects. Also severe disease's disulphide/native thiol ratio were higher than mild. Conclusion: The increased disulphide/ native thiol ratio related with the severity of coronary artery disease, may reflect the augmented oxidative stress in coronary artery disease.
dc.identifier.doi10.29333/ejgm/81878
dc.identifier.endpage33
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85039902925
dc.identifier.scopusqualityN/A
dc.identifier.startpage30
dc.identifier.urihttps://doi.org/10.29333/ejgm/81878
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5341
dc.identifier.volume14
dc.identifier.wosWOS:000419685500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBilir, Bülent
dc.institutionauthorAkkoyun, Dursun Çayan
dc.institutionauthorAydın, Murat
dc.institutionauthorÖzkaramanlı Gür, Demet
dc.language.isoen
dc.publisherModestum Ltd
dc.relation.ispartofEuropean Journal of General Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcoronary artery disease
dc.subjectdisulphide/native thiol ratio
dc.subjectoxidative stress
dc.subjectOxidative Stress
dc.subjectDamage
dc.subjectPlasma
dc.titleAssociation of coronary artery disease severity and disulphide/native thiol ratio
dc.typeArticle

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