Association of coronary artery disease severity and disulphide/native thiol ratio
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Dosyalar
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Modestum Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Oxidative stress is among the major components of cardiovascular disease pathogenesis. Thiols play a significant role in prevention of oxidative stress in the cell. The purpose of this study is to investigate the relationship between the severity of coronary artery disease and disulphide/native thiol ratio, also determine if this ratio can be used as a marker of oxidative stress in this population. Methods: A total number of 107 patients with angiographically established coronary artery disease and 26 control subjects with normal coronary arteries were enrolled. The mean Gensini score of patients were calculated (mean=30) and a score of 29 or below was considered as mild and a score of 30 or higher coronary artery disease as severe. Serum total, native thiol was measured and the disulphide and disulphide/native thiol ratio were calculated as described by Erel&Neselioglu. Results: Patients with mild and severe coronary artery disease had significantly lower native thiol levels and higher disulphide/native thiol ratio levels when compared to the control subjects. Also severe disease's disulphide/native thiol ratio were higher than mild. Conclusion: The increased disulphide/ native thiol ratio related with the severity of coronary artery disease, may reflect the augmented oxidative stress in coronary artery disease.
Açıklama
Anahtar Kelimeler
coronary artery disease, disulphide/native thiol ratio, oxidative stress, Oxidative Stress, Damage, Plasma
Kaynak
European Journal of General Medicine
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
14
Sayı
2
