Incidence, etiology, and antibiotic resistance patterns of Gram-negative microorganisms isolated from patients with ventilator-associated pneumonia in a medical-surgical intensive care unit of a teaching hospital in Istanbul, Turkey (2004-2006)

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dc.authorscopusid6602163658
dc.authorscopusid6506606196
dc.authorscopusid9843845700
dc.authorscopusid6602725339
dc.authorscopusid7003463070
dc.authorscopusid6506778903
dc.authorscopusid25622697400
dc.contributor.authorErdem, İlknur
dc.contributor.authorÖzgültekin, Asu
dc.contributor.authorİnan, Asuman Şengöz
dc.contributor.authorDinçer, E.
dc.contributor.authorTuran, G.
dc.contributor.authorCeran, Nurgül
dc.contributor.authorGöktaş, Paşa
dc.date.accessioned2022-05-11T14:42:09Z
dc.date.available2022-05-11T14:42:09Z
dc.date.issued2008
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractThe identification of microorganisms causing ventilator-associated pneumonia (VAP) is important for formulating appropriate therapies. In this study, we report the incidence, etiology, and antibiotic resistance patterns of Gram-negative microorganisms isolated from patients diagnosed with VAP in our medical-surgical intensive care unit (ICU) during the years 2004-2006. VAP was diagnosed by using the clinical criteria of the Centers for Disease Control and Prevention. Antibiotic resistance patterns of isolated microorganisms were defined by standard methods. The VAP incidence rate was 22.6/1,000 ventilator days. The most frequently isolated pathogens were Acinetobacter spp., methicillin-resistant Staphylococcus aureus, and Pseudomonas aeruginosa. Ninety percent of Acinetobacter spp. isolates were resistant to ceftazidime, 64% to imipenem, and 80% to ciprofloxacin. Fifty-nine percent of P. aeruginosa isolates were resistant to ceftazidime, 32% to imipenem, and 62% to ciprofloxacin. Cefoperazone-sulbactam was the most active agent against Acinetobacter spp. In conclusion, the incidence of VAP and the prevalence of multidrug-resistant microorganisms are quite high in our ICU. Comparison of the resistance rates of isolates demonstrates that certain antibiotic agents are more effective than others.
dc.identifier.endpage342
dc.identifier.issn1344-6304
dc.identifier.issue5en_US
dc.identifier.pmid18806338
dc.identifier.scopus2-s2.0-54449085057
dc.identifier.scopusqualityQ2
dc.identifier.startpage339
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9256
dc.identifier.volume61
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErdem, İlknur
dc.language.isoen
dc.relation.ispartofJapanese Journal of Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectamikacin
dc.subjectceftazidime
dc.subjectciprofloxacin
dc.subjectimipenem
dc.subjectmeticillin
dc.subjectpiperacillin plus tazobactam
dc.subjectsulperazon
dc.subjectantiinfective agent
dc.subjectAcinetobacter
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectantibiotic resistance
dc.subjectantibiotic sensitivity
dc.subjectarticle
dc.subjectartificial ventilation
dc.subjectbacterium culture
dc.subjectbacterium isolation
dc.subjectchild
dc.subjectcontrolled study
dc.subjectEnterobacter
dc.subjectEnterobacteriaceae
dc.subjectEscherichia coli
dc.subjectfemale
dc.subjectGram negative bacterium
dc.subjecthuman
dc.subjectincidence
dc.subjectintensive care unit
dc.subjectKlebsiella pneumoniae
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmethicillin resistant Staphylococcus aureus
dc.subjectmultidrug resistance
dc.subjectpathogenesis
dc.subjectprevalence
dc.subjectPseudomonas aeruginosa
dc.subjectteaching hospital
dc.subjecttracheal aspiration procedure
dc.subjectTurkey (republic)
dc.subjectventilator associated pneumonia
dc.subjectantibiotic resistance
dc.subjectdrug effect
dc.subjectGram negative bacterium
dc.subjectGram negative infection
dc.subjectintensive care unit
dc.subjectisolation and purification
dc.subjectmicrobiological examination
dc.subjectmicrobiology
dc.subjectmiddle aged
dc.subjectpreschool child
dc.subjectstatistics
dc.subjectteaching hospital
dc.subjectTurkey (republic)
dc.subjectventilator associated pneumonia
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAnti-Bacterial Agents
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectDrug Resistance, Bacterial
dc.subjectFemale
dc.subjectGram-Negative Bacteria
dc.subjectGram-Negative Bacterial Infections
dc.subjectHospitals, Teaching
dc.subjectHumans
dc.subjectIncidence
dc.subjectIntensive Care Units
dc.subjectMale
dc.subjectMicrobial Sensitivity Tests
dc.subjectMiddle Aged
dc.subjectPneumonia, Ventilator-Associated
dc.subjectTurkey
dc.titleIncidence, etiology, and antibiotic resistance patterns of Gram-negative microorganisms isolated from patients with ventilator-associated pneumonia in a medical-surgical intensive care unit of a teaching hospital in Istanbul, Turkey (2004-2006)
dc.typeArticle

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