Incidence, etiology, and antibiotic resistance patterns of Gram-negative microorganisms isolated from patients with ventilator-associated pneumonia in a medical-surgical intensive care unit of a teaching hospital in Istanbul, Turkey (2004-2006)
Yükleniyor...
Dosyalar
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The identification of microorganisms causing ventilator-associated pneumonia (VAP) is important for formulating appropriate therapies. In this study, we report the incidence, etiology, and antibiotic resistance patterns of Gram-negative microorganisms isolated from patients diagnosed with VAP in our medical-surgical intensive care unit (ICU) during the years 2004-2006. VAP was diagnosed by using the clinical criteria of the Centers for Disease Control and Prevention. Antibiotic resistance patterns of isolated microorganisms were defined by standard methods. The VAP incidence rate was 22.6/1,000 ventilator days. The most frequently isolated pathogens were Acinetobacter spp., methicillin-resistant Staphylococcus aureus, and Pseudomonas aeruginosa. Ninety percent of Acinetobacter spp. isolates were resistant to ceftazidime, 64% to imipenem, and 80% to ciprofloxacin. Fifty-nine percent of P. aeruginosa isolates were resistant to ceftazidime, 32% to imipenem, and 62% to ciprofloxacin. Cefoperazone-sulbactam was the most active agent against Acinetobacter spp. In conclusion, the incidence of VAP and the prevalence of multidrug-resistant microorganisms are quite high in our ICU. Comparison of the resistance rates of isolates demonstrates that certain antibiotic agents are more effective than others.
Açıklama
Anahtar Kelimeler
amikacin, ceftazidime, ciprofloxacin, imipenem, meticillin, piperacillin plus tazobactam, sulperazon, antiinfective agent, Acinetobacter, adolescent, adult, aged, antibiotic resistance, antibiotic sensitivity, article, artificial ventilation, bacterium culture, bacterium isolation, child, controlled study, Enterobacter, Enterobacteriaceae, Escherichia coli, female, Gram negative bacterium, human, incidence, intensive care unit, Klebsiella pneumoniae, major clinical study, male, methicillin resistant Staphylococcus aureus, multidrug resistance, pathogenesis, prevalence, Pseudomonas aeruginosa, teaching hospital, tracheal aspiration procedure, Turkey (republic), ventilator associated pneumonia, antibiotic resistance, drug effect, Gram negative bacterium, Gram negative infection, intensive care unit, isolation and purification, microbiological examination, microbiology, middle aged, preschool child, statistics, teaching hospital, Turkey (republic), ventilator associated pneumonia, Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Child, Child, Preschool, Drug Resistance, Bacterial, Female, Gram-Negative Bacteria, Gram-Negative Bacterial Infections, Hospitals, Teaching, Humans, Incidence, Intensive Care Units, Male, Microbial Sensitivity Tests, Middle Aged, Pneumonia, Ventilator-Associated, Turkey
Kaynak
Japanese Journal of Infectious Diseases
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
61
Sayı
5
