Evaluation of the oxytocin effect in a rat model with experimental periodontitis

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dc.authoridKoca-Unsal, Revan Birke/0000-0003-1540-983X
dc.authoridOrhan, Kaan/0000-0001-6768-0176
dc.authoridSEHIRLI, AHMET OZER/0000-0002-5175-9290
dc.authoridPaksoy, Tugce/0000-0001-6204-7304
dc.authorscopusid57216226536
dc.authorscopusid56652230900
dc.authorscopusid6603160775
dc.authorscopusid57893899000
dc.authorscopusid35118130800
dc.authorscopusid8502419700
dc.authorscopusid57892441400
dc.authorwosidŞehirli, Ahmet Ozer/ABA-5455-2020
dc.contributor.authorPaksoy, Tuğçe
dc.contributor.authorUstaoğlu, Gülbahar
dc.contributor.authorSehirli, Ahmet Özer
dc.contributor.authorÜnsal, Revan Birke Koca
dc.contributor.authorSayıner, Serkan
dc.contributor.authorOrhan, Kaan
dc.contributor.authorAksoy, Umut
dc.contributor.authorAycı, Nurdan Bülbül
dc.date.accessioned2023-04-20T08:01:16Z
dc.date.available2023-04-20T08:01:16Z
dc.date.issued2022
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe aim of the present study was to evaluate the inhibitory effects of oxytocin on the development of periodontitis based on its properties against bone loss and resorption. Thirty-two Wistar albino rats were divided into four equal groups: control, periodontitis + saline, periodontitis + 0.5 mg/kg/day oxytocin, and periodontitis + 1 mg/kg/day oxytocin. Periodontitis groups received 4.0 silk ligatures around their cervixes of the right and left mandibular incisors in an 8 shape, kept for 14 days. Animals in oxytocin groups were injected once every day during 14 days with oxytocin. The mandibles were fixed and scanned using microcomputed tomography to quantify bone resorption and volumetric measurements. Blood samples were collected to analyze the concentrations of macrophage colony-stimulating factor (M-CSF), receptor activator of nuclear factor-kappa Beta ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase-8 (MMP-8), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, glutathione peroxidase (GPx), superoxide dismutase (SOD), and malondialdehyde (MDA). Histopathological evaluations were conducted to examine the gingiva and alveolar bone. Oxytocin prevented the development of periodontitis by decreasing ligament deteriorations and leukocytes in the gingival connective tissue and promoting reintegration with the alveolar bone. Bone resorption in all regions was less in the periodontitis + 1 mg/kg/day oxytocin group than in the periodontitis + saline group. Although TNF-alpha, IL-6, and RANKL values were lower in the periodontitis + 1 mg/kg/day oxytocin group, OPG was higher than that in the periodontitis + saline group. M-CSF, MMP-8, and MDA were lower in the oxytocin groups than in the periodontitis + saline group. Oxytocin may be an effective agent for periodontal diseases because it decreased bone resorption, oxidative stress, and inflammation in an experimental periodontitis.
dc.identifier.doi10.1007/s00210-022-02293-5
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.pmid36114855
dc.identifier.scopus2-s2.0-85138188711
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s00210-022-02293-5
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10835
dc.identifier.wosWOS:000854829900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAycı, Nurdan Bülbül
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofNaunyn-Schmiedebergs Archives of Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlveolar Bone Loss
dc.subjectAntioxidant
dc.subjectOxytocin
dc.subjectPeriodontal Diseases
dc.subjectRats
dc.subjectIschemia-Reperfusion Injury
dc.subjectBone-Formation
dc.subjectStem-Cells
dc.subjectDamage
dc.subjectDifferentiation
dc.subjectInflammation
dc.titleEvaluation of the oxytocin effect in a rat model with experimental periodontitis
dc.typeArticle

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