Immediate post-operative intravesical instillation of a single dose chemotherapy is not superior to continuous saline irrigation

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dc.authorscopusid7006257566
dc.authorscopusid57209469905
dc.authorscopusid8899180900
dc.authorscopusid36151868000
dc.authorscopusid7003764995
dc.authorscopusid55505478700
dc.authorscopusid7005454841
dc.contributor.authorTürkeri, L.
dc.contributor.authorKarşıyakalı, N.
dc.contributor.authorAslan, G.
dc.contributor.authorAkgül, Murat
dc.contributor.authorBaltacı, S.
dc.contributor.authorBolat, D.
dc.contributor.authorTınay, İ.
dc.date.accessioned2023-04-20T08:04:17Z
dc.date.available2023-04-20T08:04:17Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractIntroduction and objectives: To evaluate whether there is any difference between immediate postoperative instillation of intravesical chemotherapy (IPOIC) and continuous saline bladder irrigation(CSBI) in terms of bladder cancer(BC) recurrence in patients with primary low- or intermediate-risk non-muscle-invasive BC (NMIBC). Materials and methods: Medical records of 1482 patients who underwent transurethral resection of bladder tumor between March 1994 and August 2020 were reviewed retrospectively. Patients were divided into two groups according to IPOIC and/or CSBI administration status (Group 1: CSBI alone; Group 2: CSBI following IPOIC). Low- and intermediate-risk NMIBC patients were also divided into subgroups according to IPOIC and/or CSBI administration status. Results: A total of 594 patients with primary NMIBC were included. Of the patients, 86 (14.5%) were female and 508 (85.5%) were male with a median age of 69 (60-78) years. The frequency of patients in group 1 and group 2 were 361 (60.8%) and 233 (39.2%), respectively. Recurrent disease was observed in 213 (35.9%) patients. There was no difference between the groups when they were compared for recurrent disease frequency, median time to first recurrence and frequency of recurrence within first 12 months (P=.064, P=.671, and P=.145, respectively). Disease recurrence rates in low-risk NMIBC patients was lower when they were treated with “CSBI following IPOIC” when compared to “CSBI alone” (P=.042). However, no difference was observed in low-risk NMIBC subgroups when they were compared for pathological features of recurrent tumors such as number, size, grade, stage, and presence of carcinoma in situ (P>.05, for each). Conclusions: “CSBI following IPOIC” combination was not superior to “CSBI alone” for preventing adverse pathological outcomes in recurrent low- and intermediate-risk NMIBC. © 2022 AEU
dc.description.sponsorshipAgradecemos a Murat Bozlu MD, profesor del Departamento de Urología, Facultad de Medicina, Universidad de Mersin.
dc.identifier.doi10.1016/j.acuro.2021.11.008
dc.identifier.issn0210-4806
dc.identifier.pmid36089504
dc.identifier.scopus2-s2.0-85131376635
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1016/j.acuro.2021.11.008
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11074
dc.identifier.wosWOS:000869092800003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkgül, Murat
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofActas Urologicas Espanolas
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectContinuous saline bladder irrigation
dc.subjectImmediate postoperative instillation of intravesical chemotherapy
dc.subjectIntravesical chemotherapy
dc.subjectnon-muscle-invasive bladder cancer
dc.subjectTransurethral resection of bladder tumors
dc.subjectaged
dc.subjectbladder
dc.subjectbladder tumor
dc.subjectfemale
dc.subjecthuman
dc.subjectintravesical drug administration
dc.subjectmale
dc.subjectprevention and control
dc.subjectretrospective study
dc.subjecttumor recurrence
dc.subjectAdministration, Intravesical
dc.subjectAged
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectNeoplasm Recurrence, Local
dc.subjectRetrospective Studies
dc.subjectUrinary Bladder
dc.subjectUrinary Bladder Neoplasms
dc.titleImmediate post-operative intravesical instillation of a single dose chemotherapy is not superior to continuous saline irrigation
dc.title.alternativeLa dosis única de instilación intravesical postoperatoria inmediata de quimioterapia no es superior al lavado continuo con suero
dc.typeArticle

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