Immediate post-operative intravesical instillation of a single dose chemotherapy is not superior to continuous saline irrigation
No Thumbnail Available
Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Ltd
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Introduction and objectives: To evaluate whether there is any difference between immediate postoperative instillation of intravesical chemotherapy (IPOIC) and continuous saline bladder irrigation(CSBI) in terms of bladder cancer(BC) recurrence in patients with primary low- or intermediate-risk non-muscle-invasive BC (NMIBC). Materials and methods: Medical records of 1482 patients who underwent transurethral resection of bladder tumor between March 1994 and August 2020 were reviewed retrospectively. Patients were divided into two groups according to IPOIC and/or CSBI administration status (Group 1: CSBI alone; Group 2: CSBI following IPOIC). Low- and intermediate-risk NMIBC patients were also divided into subgroups according to IPOIC and/or CSBI administration status. Results: A total of 594 patients with primary NMIBC were included. Of the patients, 86 (14.5%) were female and 508 (85.5%) were male with a median age of 69 (60-78) years. The frequency of patients in group 1 and group 2 were 361 (60.8%) and 233 (39.2%), respectively. Recurrent disease was observed in 213 (35.9%) patients. There was no difference between the groups when they were compared for recurrent disease frequency, median time to first recurrence and frequency of recurrence within first 12 months (P=.064, P=.671, and P=.145, respectively). Disease recurrence rates in low-risk NMIBC patients was lower when they were treated with “CSBI following IPOIC” when compared to “CSBI alone” (P=.042). However, no difference was observed in low-risk NMIBC subgroups when they were compared for pathological features of recurrent tumors such as number, size, grade, stage, and presence of carcinoma in situ (P>.05, for each). Conclusions: “CSBI following IPOIC” combination was not superior to “CSBI alone” for preventing adverse pathological outcomes in recurrent low- and intermediate-risk NMIBC. © 2022 AEU
Description
Keywords
Continuous saline bladder irrigation, Immediate postoperative instillation of intravesical chemotherapy, Intravesical chemotherapy, non-muscle-invasive bladder cancer, Transurethral resection of bladder tumors, aged, bladder, bladder tumor, female, human, intravesical drug administration, male, prevention and control, retrospective study, tumor recurrence, Administration, Intravesical, Aged, Female, Humans, Male, Neoplasm Recurrence, Local, Retrospective Studies, Urinary Bladder, Urinary Bladder Neoplasms
Journal or Series
Actas Urologicas Espanolas
WoS Q Value
Q4
Scopus Q Value
Q3
