Immunohistochemical Distribution of Somatostatin in Gastric Tissue of Diabetic Rats Treated with Cinnamon Extract

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dc.authorscopusid34971025700
dc.authorscopusid37121662100
dc.authorscopusid57209341373
dc.authorscopusid55236851900
dc.authorscopusid27667663200
dc.authorwosidbakır, buket/ABA-8248-2020
dc.authorwosiddağ, serpil/AAZ-6755-2020
dc.contributor.authorEliş Yıldız, Sevda
dc.contributor.authorBakır, Buket
dc.contributor.authorYediel Aras, Sukran
dc.contributor.authorDağ, Serpil
dc.contributor.authorKaradağ Sarı, Ebru
dc.date.accessioned2022-05-11T14:42:29Z
dc.date.available2022-05-11T14:42:29Z
dc.date.issued2019
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractDiabetes is a chronic metabolic disorder, as well as a situation of increased oxidative stress. We examined the distribution of somatostatin in gastric tissues of cinnamon extract treated streptozotocin-induced diabetic rats using the immunohistochemistry technique. A total of 30 male Sprague Dawley rats were used in the study. The rats were assigned to five groups as control, sham, cinnamon, diabetes and diabetes + cinnamon. No application was made to the control group, the sham group received intraperitoneally (1.p.) 50 mg/kg sodium citrate, and diabetes was induced by i.p. injection of 50 mg/kg STZ in diabetes and diabetes + cinnamon groups. Cinnamon extracts were then given to cinnamon and diabetes + cinnamon groups by oral gavage at a dose of 200 mg/kg for 14 days. The streptavidin-biotin-peroxidase method was used to determine the immunoreactivity of somatostatin. Gastric tissue sections were prepared and stained by Crossman's triple and Hematoxyl in-Eosin staining in order to examine histological structure of the gastric tissue. We determined that somatostatin immunoreactivity of the control, sham and cinnamon groups was stronger than for the diabetes, and diabetes + cinnamon groups. While a weak immunoreactivity was found in the cardia, fundus and pyloric mucosa of the gastric tissue in the diabetes and diabetes + cinnamon groups, a strong immunoreactivity was found in the cinnamon, sham, and control groups. Also, a statistically significant was observed when all groups compared in terms of count of parietal and principal cells (P<0.001). It was determined that there was a statistically significant difference between diabetes, diabetes + cinnamon groups and control, sham, cinnamon groups in terms of fasting blood glucose levels (P<0.05). In conclusion, somatostatin, which plays an important role in gastroduodenal diseases, was found to be lower in the diabetes and cinnamon + diabetes groups.
dc.identifier.doi10.9775/kvfd.2018.21175
dc.identifier.endpage433
dc.identifier.issn1300-6045
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85067450849
dc.identifier.scopusqualityQ3
dc.identifier.startpage427
dc.identifier.urihttps://doi.org/10.9775/kvfd.2018.21175
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9389
dc.identifier.volume25
dc.identifier.wosWOS:000460503100020
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBakır, Buket
dc.language.isoen
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisi
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCinnamon
dc.subjectDiabetes
dc.subjectGastric
dc.subjectlmmunohistochemistry
dc.subjectSomatostatin
dc.subjectBlood-Glucose
dc.subjectEndocrine-Cells
dc.subjectSecretion
dc.subjectStomach
dc.subjectBark
dc.titleImmunohistochemical Distribution of Somatostatin in Gastric Tissue of Diabetic Rats Treated with Cinnamon Extract
dc.title.alternativeTarçın ekstraktı ıle tedavi edilen diyabetik sıçanların mide dokusunda somatostatinin ımmunohistokimyasal dağılımı]
dc.typeArticle

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