EVALUATION OF NEW INFLAMMATORY PARAMETERS IN PATIENTS WITH CHRONIC SPONTANEOUS URTICARIA: A NEW PREDICTOR OF REFRACTORINESS TO ANTIHISTAMINE TREATMENT

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dc.contributor.authorCosansu, Nur Cihan
dc.date.accessioned2024-10-29T17:53:22Z
dc.date.available2024-10-29T17:53:22Z
dc.date.issued2020
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractAim: Antihistamines is used as the first-line treatment in chronic spontaneous urticaria (CSU). We investigated whether complet blood count parameters might be used as a response factor in patients under antihistamine treatment for CSU. We also compared the NLR (neutrophil lymphocyte ratio), PLR (platelet lymphocyte ratio, MPV (mean platelet volume) and RDW (erythrocyte distribution width)levels of CSU patients with healthy controls.Materials and Methods: This study was conducted on a total of 150 cases, a hundred of which had CSU and fifty healthy control group.Results: NLR and RDW were significantly higher and MPV was significantly lower in the CSU group. NLR and PLR levels were found significantly lower in patients who responded to antihistamine treatment within 4 weeks. The ROC analysis showed that NLR predicted responders with a sensitivity of 92% and with a specificity of 84%, using a cut-off value of 1,98 (p<.001). The multivariate regression analysis showed that only NLR was found as the predictor of responders.Conclusion: NLR may be considered as a simple and cost-effective tool to determine which patients can respond to antihistamines. It may be a guide for non-responsive patients to switch to other treatment options in the early period.
dc.identifier.doi10.37696/nkmj.731617
dc.identifier.endpage411
dc.identifier.issn2587-0262
dc.identifier.issue3en_US
dc.identifier.startpage404
dc.identifier.trdizinid413181
dc.identifier.urihttps://doi.org/10.37696/nkmj.731617
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/413181
dc.identifier.urihttps://hdl.handle.net/20.500.11776/13539
dc.identifier.volume8
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofNamık Kemal Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEVALUATION OF NEW INFLAMMATORY PARAMETERS IN PATIENTS WITH CHRONIC SPONTANEOUS URTICARIA: A NEW PREDICTOR OF REFRACTORINESS TO ANTIHISTAMINE TREATMENT
dc.typeArticle

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