Histiocytic Sarcoma with Invasive Urothelial Carcinoma of Urinary Bladder
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Dosyalar
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
College of Physicians and Surgeons Pakistan
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We report a rare case of histiocytic sarcoma in association with invasive urothelial carcinoma involving the urinary bladder. A 67-year male patient, who presented with a complaint of macroscopic hematuria, was found to have a mass on urinary system ultrasonography. Abdominal magnetic resonance imaging was performed to evaluate the mass, which showed a 52×24 mm mass on the posterior wall of the bladder. The cystoscopic examination revealed two suspicious areas in close proximity to one another with solid-papillary character. The tissue samples were collected by means of transurethral resection. The evaluation of these samples revealed two distinct neoplastic patterns. The areas of invasive urothelial carcinoma infiltrating lamina propria were noted on the surface in addition to diffuse sheets of large cells with hyperchromatic nuclei and ample clear cytoplasm, with a patternless pattern among small lymphocytes in myxoid background in the lamina propria. The positive reactions were observed in these areas with CD45, fascin, and CD68, a histiocytic marker. The histopathological diagnosis was histiocytic sarcoma in combination with invasive urothelial carcinoma. Histiocytic sarcoma may mimic several other malignant lesions, and only immunohistochemistry can identify this tumour to allow correct treatment. We present this rare case to emphasise that this phenomenon should be considered in unusual tumors and sites. © 2022 College of Physicians and Surgeons Pakistan. All rights reserved.
Açıklama
Anahtar Kelimeler
Histiocytic sarcoma, Invasive urothelial carcinoma, Urinary bladder, CD68 antigen, fascin, receptor type tyrosine protein phosphatase C, abdominal radiography, aged, Article, bladder tumor, cancer infiltration, cancer staging, case report, clinical article, cystoprostatectomy, cystoscopy, cytology, cytoplasm, differential diagnosis, disease association, echography, follow up, hematuria, histiocytic sarcoma, histopathology, human, human cell, human tissue, immunohistochemistry, lamina propria, lymph node dissection, lymphocyte structure, lymphoma, male, melanoma, neuroendocrine carcinoma, nuclear magnetic resonance imaging, postoperative period, prostate tissue, transitional cell carcinoma, transurethral resection, tumor invasion, tumor volume, bladder, bladder tumor, cystectomy, diagnostic imaging, pathology, transitional cell carcinoma, Carcinoma, Transitional Cell, Cystectomy, Histiocytic Sarcoma, Humans, Male, Urinary Bladder, Urinary Bladder Neoplasms
Kaynak
Journal of the College of Physicians and Surgeons Pakistan
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
32
Sayı
6
