Detection of prion gene promoter and intron1 indel polymorphisms in Anatolian water buffalo (Bubalus bubalis)

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dc.authorid0000-0001-7460-4040
dc.authorid0000-0002-0591-1570
dc.authorscopusid8712523200
dc.authorscopusid8431541400
dc.authorscopusid35491990300
dc.authorscopusid35183788500
dc.authorscopusid24779770200
dc.authorwosidOztabak, Kemal Ozdem/AAC-5810-2021
dc.authorwosidün, cemal/AAH-3099-2020
dc.authorwosidÜnal, Emel Özkan/ABA-3367-2020
dc.contributor.authorÖztabak, Kemal
dc.contributor.authorÖzkan Ünal, Emel
dc.contributor.authorSoysal, İhsan
dc.contributor.authorPaya, I.
dc.date.accessioned2022-05-11T14:46:18Z
dc.date.available2022-05-11T14:46:18Z
dc.date.issued2009
dc.departmentFakülteler, Ziraat Fakültesi, Zootekni Bölümü
dc.description.abstractP>Bovine spongiform encephalopathy (BSE) is a fatal disease caused by miss folded prion protein. Studies in the cattle, comparing genetic data from BSE diseased and healthy animals have shown that indel polymorphisms in the promoter and intron 1 of PRNP gene were associated with disease susceptibility. Several studies were conducted to find out allele and genotypic frequencies of indel polymorphisms in promoter and intron 1 of the cattle PRNP gene. Unlike domestic cattle and bison, no indel polymorphisms of the PRNP promoter and intron 1 were examined in any population of the water buffalo (Bubalus bubalis). Aim of this study was to analyse frequencies of allele, genotype, and haplotype of the indel polymorphisms (23 bp indel in promoter and 12 bp indel in intron 1) in prion protein coding gene (PRNP) of water buffalo. Therefore a PCR based procedure, previously used in cattle to detect indel polymorphisms of PRNP promoter and intron 1 locus, was applied to 106 Anatolian water buffalo DNAs. Our results have revealed high frequency of in variants and in23/in12 haplotype for PRNP promoter and intron 1 indel polymorphisms in water buffalo. The results of the study have demonstrated that frequencies of allele, genotype, and haplotype of the indel polymorphisms in PRNP gene of the Anatolian water buffalo are significantly different those from cattle and bison PRNP indel polymorphisms.
dc.identifier.doi10.1111/j.1439-0388.2009.00821.x
dc.identifier.endpage467
dc.identifier.issn0931-2668
dc.identifier.issn1439-0388
dc.identifier.issue6en_US
dc.identifier.pmid19912420
dc.identifier.scopus2-s2.0-73449120732
dc.identifier.scopusqualityQ1
dc.identifier.startpage463
dc.identifier.urihttps://doi.org/10.1111/j.1439-0388.2009.00821.x
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10273
dc.identifier.volume126
dc.identifier.wosWOS:000271785700007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkan Ünal, Emel
dc.institutionauthorSoysal, İhsan
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Animal Breeding and Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectindel polymorphisms
dc.subjectPRNP
dc.subjectwater buffalo
dc.subjectProtein Gene
dc.subjectPotential Association
dc.subjectPrnp Gene
dc.subjectUs Cattle
dc.subjectBse
dc.subjectSusceptibility
dc.subjectPopulation
dc.subjectGenotypes
dc.subjectHolstein
dc.subjectScrapie
dc.titleDetection of prion gene promoter and intron1 indel polymorphisms in Anatolian water buffalo (Bubalus bubalis)
dc.typeArticle

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