Toxicological assessment of low-dose bisphenol A, lead and endosulfan combination: chronic toxicity study in male rats

Basit Öğe Kaydı
dc.authorscopusid26434143900
dc.authorscopusid55838809000
dc.authorscopusid23968920100
dc.authorscopusid56816914100
dc.authorscopusid55858591400
dc.contributor.authorDökmeci, Ayşe Handan
dc.contributor.authorKaraboğa, İhsan
dc.contributor.authorGüzel, S.
dc.contributor.authorErboğa, Zeynep Fidanol
dc.contributor.authorYılmaz, A.
dc.date.accessioned2022-05-11T14:02:43Z
dc.date.available2022-05-11T14:02:43Z
dc.date.issued2022
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractIn the present study, toxic effects, both alone and combined, of bisphenol A (BPA), lead (Pb) and endosulfan (ES) in the low doses were investigated in rat liver and kidney functions. In the study, bisphenol A (BPA), lead (Pb) and endosulfan (ES) were chosen because although they are the chemicals people are most frequently exposed to, no combined toxic effect studies were conducted with these chemicals. Sixty-four male Wistar albino rats were used in the study, and they were randomly divided into eight groups (n = 8 per group); control, BPA (5 mg/kg), Pb (100 ppm), ES (0.61 mg/kg), BPA+Pb, BPA+ES, Pb+ES and BPA+P+ES. The rats were sacrificed after 65 days of treatment. Severe histopathological changes in the liver and kidney tissues were observed in the rats exposed to BPA+Pb+ES combination. Elevated malondialdehyde (MDA) in the liver and decreased superoxide dismutase activity (SOD) in the kidney tissue were detected in the BPA+Pb+ES group compared to those of the control group. It was found that serum alanine aminotransferase (ALT) and blood urea nitrogen (BUN) and creatinine (CREA) levels were higher in the BPA+Pb+ES combination group than the control group. Also, combined exposure of BPA, Pb and ES caused apoptotic cell numbers and inducible nitric oxide (iNOS) to increase in the liver and kidney tissues. The results of the present study suggested that the BPA, Pb and ES caused more dramatic changes to both histological architecture and cell apoptosis in the liver and kidney tissues when there was a combined exposure. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
dc.description.sponsorshipOur study was supported by Tekirdag Namik Kemal University, Scientific Research Projects Commission, Project number; NKUBAP.23.DS.18.165.
dc.identifier.doi10.1007/s11356-021-16407-8
dc.identifier.endpage10574
dc.identifier.issn0944-1344
dc.identifier.issue7en_US
dc.identifier.pmid34523106
dc.identifier.scopus2-s2.0-85114900458
dc.identifier.scopusqualityQ1
dc.identifier.startpage10558
dc.identifier.urihttps://doi.org/10.1007/s11356-021-16407-8
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4454
dc.identifier.volume29
dc.identifier.wosWOS:000695805700004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDökmeci, Ayşe Handan
dc.institutionauthorKaraboğa, İhsan
dc.institutionauthorGüzel, S.
dc.institutionauthorErboğa, Zeynep Fidanol
dc.institutionauthorYılmaz, A.
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofEnvironmental Science and Pollution Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectBisphenol A
dc.subjectEndosulfan
dc.subjectInducible nitric oxide synthase
dc.subjectLead
dc.subjectMixture toxicity
dc.subjectapoptosis
dc.subjectendosulfan
dc.subjectenzyme activity
dc.subjectlead
dc.subjectnitric oxide
dc.subjectserum
dc.subjecttoxicity
dc.subjecttoxicology
dc.subjecturea
dc.subject4,4' isopropylidenediphenol
dc.subjectbenzhydryl derivative
dc.subjectendosulfan
dc.subjectlead
dc.subjectphenol derivative
dc.subjectanimal
dc.subjectliver
dc.subjectmale
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectrat
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectBenzhydryl Compounds
dc.subjectEndosulfan
dc.subjectLead
dc.subjectLiver
dc.subjectMale
dc.subjectOxidative Stress
dc.subjectPhenols
dc.subjectRats
dc.subjectRats, Wistar
dc.titleToxicological assessment of low-dose bisphenol A, lead and endosulfan combination: chronic toxicity study in male rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
4454.pdf
Boyut:
3.83 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Sağlık Yüksekokulu Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu