Predictors of lymphovascular invasion in estrogen receptor positive/Her-2 negative breast cancer patients treated with neoadjuvant chemotherapy
Yükleniyor...
Dosyalar
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkiye Klinikleri
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background/aim: Lymphovascular invasion (LVI) is considered a high-risk factor for recurrence in early-stage breast cancer, hence examination of LVI in pathological samples is an absolute recommendation. We aim to investigate predictive factors of LVI in pre-neoadjuvant chemotherapy (NAC) patients with estrogen receptor positive (ER+) and human epidermal growth factor receptor 2 negative (HER2-) molecular subtypes of breast cancer. Materials and methods: One hundred and thirty-four patients treated with NAC were included in this study who were ER+/HER2-. The clinical characteristics of the patients, the data obtained from the core needle biopsy before NAC and the LVI status in the pathology that examined after breast surgery were collected. Univariate and multivariate analysis were performed using the logistic regression model. Results: An examination of the association between LVI and clinical-pathological patient characteristics showed that advanced age (>40 years old) (p = 0.021), ductal histology (p = 0.039), and presence of axillary lymph node metastasis (p = 0.005) were predictors of LVI. Independent predictors of LVI in a multivariate logistic model included advanced age (p = 0.037), and the presence of axillary lymph node metastasis prior to NAC (p = 0.006). The median RFS (Recurrence-free survival) time was 22.8 months for all patients. RFS was shorter in patients with LVI (log-rank p = 0.037). Conclusion: Independent predictors of LVI are advanced age and lymph node positivity at the time of diagnosis. Our study is the first study that evaluates pre-NAC predictive factors of LVI in ER+/HER2-breast cancer patients treated with NAC. © TÜBİTAK.
Açıklama
Anahtar Kelimeler
Breast cancer, chemotherapy, lymphovascular invasion, predictive, alpha smooth muscle actin, CD34 antigen, cyclophosphamide, cytokeratin 7, docetaxel, epirubicin, estrogen receptor, Ki 67 antigen, paclitaxel, progesterone receptor, protein p63, uvomorulin, adjuvant therapy, adult, aged, aging, Article, axillary lymph node, breast cancer recurrence, cancer hormone therapy, distant metastasis, echography, estrogen receptor-positive, HER2-negative breast cancer, female, fluorescence in situ hybridization, follow up, histology, human, human tissue, immunohistochemistry, lymph node biopsy, lymph node metastasis, lymph vessel metastasis, major clinical study, multiple cycle treatment, needle biopsy, neoadjuvant chemotherapy, nuclear magnetic resonance imaging, positron emission tomography-computed tomography, protein expression, recurrence free survival, retrospective study, thorax radiography, tumor volume
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
52
Sayı
4
