Addition of tetraethylthiuram disulfide to antimony(III) iodide; synthesis, characterization and biological activity

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dc.authorid0000-0003-3164-0038
dc.authorid0000-0003-3264-2406
dc.authorid0000-0001-9556-6266
dc.authorid0000-0002-4804-3822
dc.authorid0000-0003-1188-6233
dc.authorid0000-0001-6727-2711
dc.authorscopusid55227384500
dc.authorscopusid36785856200
dc.authorscopusid46860923200
dc.authorscopusid6507202525
dc.authorscopusid14525091600
dc.authorscopusid6602706096
dc.authorscopusid6602925165
dc.authorwosidOzturk, Ibrahim Ismet/K-1352-2013
dc.authorwosidKourkoumelis, Nikolaos/B-8555-2009
dc.authorwosidHadjikakou, Sotiris K./I-2909-2019
dc.authorwosidürgüt, ozan suleyman/ABA-5795-2020
dc.contributor.authorUrgut, O. S.
dc.contributor.authorÖztürk, İbrahim İsmet
dc.contributor.authorBanti, Christina N.
dc.contributor.authorKourkoumelis, Nikolaos
dc.contributor.authorManoli, Maria
dc.contributor.authorTasiopoulos, Anastasios J.
dc.contributor.authorHadjikakou, Sotiris K.
dc.date.accessioned2022-05-11T14:30:54Z
dc.date.available2022-05-11T14:30:54Z
dc.date.issued2016
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractThree new antimony(III) iodide complexes with the N,N-diethylcarbamodithioic acid of formulae {[(SbI(Et2DTC)(2))(I-2)](n)} (1), {[(Sb(Et2DTC)(2))(4) (SbI6) (I-3)](n)} (2) and {[SbI(Et2DTC)(2)](2)} (3), (Et2DTCH: N,N-diethylcarbamodithioic acid, C5H11NS2) were synthesized from the reaction of antimony(III) iodide with tetraethylthiuram disulfide in 1: 1 stoichiometry. The complexes 1-3 were characterized by melting point, elemental analysis, FT-IR spectroscopy, Raman spectroscopy, H-1, C-13 NMR spectroscopy and Thermal Gravimetry-Differential Thermal Analysis (TG-DTA). Moreover, crystal structures of complexes 1-3 were determinated with single crystal X-ray diffraction analysis. Complexes 1-3 derived from ligand reduction with concomitant degradation of the tetraethylthiuram disulfide to dithiocarbamates. Complexes 1 and 2 are polymer but complex 3 is dimmer. Complex 1 consists of two residues, [SbI (Et2DTC)(2)] and [I-2], while 2 consists of three residues, four cationic [Sb(Et(2)dtc)(2)](+), one [SbI6](3-) and one [I-3](-) counter anion. Complexes 1-3 were evaluated for their in vitro cytotoxic activity against human breast adenocarcinoma (MCF-7) and human cervix adenocarcinoma (HeLa) cells. Structure Activity Relationship (SAR) studies reveal that the high activity of the complexes is positively correlated with the low H-all atoms intermolecular contacts. (C) 2016 Elsevier B.V. All rights reserved.
dc.description.sponsorshipNamik Kemal University Scientific Research ProjectNamik Kemal University [NKUBAP.00.10.YL.12.03]; National Scholarships Foundation of Greece (IKY)
dc.description.sponsorshipThis research was carried out in partial fulfillment of the requirements for the Master thesis of O.S.U., under the supervision of I.I.O., at the Namik Kemal University. I.I.O. and O.S.U. acknowledge the financial support from Namik Kemal University Scientific Research Project (Project No. NKUBAP.00.10.YL.12.03). C.N.B. and S.K.H. would like to thank the Unit of bioactivity testing of xenobiotics, the University of Ioannina, for providing access to the facilities. C.N.B. and S.K.H. acknowledge the National Scholarships Foundation of Greece (IKY) for the post doctoral research fellowship of excellence programm IKY-Siemens.
dc.identifier.doi10.1016/j.ica.2015.12.028
dc.identifier.endpage150
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopus2-s2.0-84954475947
dc.identifier.scopusqualityQ2
dc.identifier.startpage141
dc.identifier.urihttps://doi.org/10.1016/j.ica.2015.12.028
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7218
dc.identifier.volume443
dc.identifier.wosWOS:000369070900020
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖztürk, İbrahim İsmet
dc.institutionauthorÜrgüt, Ozan
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofInorganica Chimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntimony(III) complexes
dc.subjectCrystal structures
dc.subjectN,N-diethylcarbamodithioic acid
dc.subjectCytotoxicity
dc.subjectStructure Activity Relationship (SAR)
dc.subjectStructural-Characterization
dc.subjectIn-Vitro
dc.subjectMolecular-Structure
dc.subjectDiphenylantimony(Iii) Derivatives
dc.subjectCoordination Chemistry
dc.subjectCrystal-Structure
dc.subjectThiuram Sulfides
dc.subjectHalide-Complexes
dc.subjectDithiocarbamate
dc.subjectBismuth(Iii)
dc.titleAddition of tetraethylthiuram disulfide to antimony(III) iodide; synthesis, characterization and biological activity
dc.typeArticle

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