In vivo protective effects of upper zone of growth plate and cartilage matrix associated protein against cartilage degeneration in a monosodium iodoacetate induced osteoarthritis model

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dc.authorscopusid56047982200
dc.authorscopusid55963510600
dc.authorscopusid55838809000
dc.authorscopusid57219858233
dc.authorscopusid8855265500
dc.contributor.authorOkuyan, H.M.
dc.contributor.authorTerzi, M.Y.
dc.contributor.authorKaraboğa, İhsan
dc.contributor.authorDoğan, S.
dc.contributor.authorKalacı, A.
dc.date.accessioned2022-05-11T14:07:27Z
dc.date.available2022-05-11T14:07:27Z
dc.date.issued2020
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü
dc.description.abstractOsteoarthritis (OA) is a degenerative disease affecting the majority of over 65 year old people and characterized by cartilage degeneration, subchondral abnormal changes, and inflammation. Despite the enormous socioeconomic burden caused by OA, currently, there is no effective therapy against it. Upper zone of growth plate and cartilage matrix associated protein (UCMA) is a vitamin K dependent protein and has a critical role in pathophysiological conditions associated with bone and cartilage. However, there is no research on the protective role of intra-articular UCMA treatment in OA pathogenesis. Therefore, we aimed to investigate the potential therapeutic role of UCMA in an in vivo model of OA. We report for the first time that intra-articular UCMA injection ameliorated cartilage degeneration in a monosodium iodoacetate induced OA rat model. Furthermore, the OA-induced activation of nuclear factor kappa B and bone morphogenetic protein 2 signals was attenuated by UCMA. Our results indicated that UCMA decreased cartilage oligomeric matrix protein levels but did not affect interleukin 6, total antioxidant status, and total oxidant status levels in the serum. In conclusion, UCMA exhibited a therapeutic potential in the treatment of OA. This protective effect of UCMA is possibly achieved by reducing the aggrecanase activity and the production of inflammatory cytokines. © 2020, Canadian Science Publishing. All rights reserved.
dc.description.sponsorshipMustafa Kemal Üniversitesi
dc.description.sponsorshipThis work was supported by the Scientific Research Project Fund of Hatay Mustafa Kemal University. Author contributions: H.M.O. conceived and designed the study. H.M.O., M.Y.T., İ.K., S.D., and A.K. wrote/drafted/edited the manuscript and interpreted the results. H.M.O., M.Y.T., İ.K., S.D., and A.K. performed experiments and laboratory analysis. H.M.O., M.Y.T., İ.K., and S.D. conducted analyses, prepared graphs/figures, and revised the manuscript.
dc.identifier.doi10.1139/cjpp-2020-0009
dc.identifier.endpage770
dc.identifier.issn0008-4212
dc.identifier.issue11en_US
dc.identifier.pmid32640182
dc.identifier.scopus2-s2.0-85095771848
dc.identifier.scopusqualityQ3
dc.identifier.startpage763
dc.identifier.urihttps://doi.org/10.1139/cjpp-2020-0009
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5107
dc.identifier.volume98
dc.identifier.wosWOS:000589887900003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaraboğa, İhsan
dc.language.isoen
dc.publisherCanadian Science Publishing
dc.relation.ispartofCanadian Journal of Physiology and Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCartilage degeneration
dc.subjectMonosodium iodoacetate
dc.subjectOsteoarthritis
dc.subjectOxidative stress
dc.subjectRat osteoarthritis model
dc.subjectTotal antioxidant status
dc.subjectTotal oxidant status
dc.subjectUCMA
dc.subjectantirheumatic agent
dc.subjectbone morphogenetic protein 2
dc.subjectcartilage oligomeric matrix protein
dc.subjectdiclofenac
dc.subjectglycosaminoglycan
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectinterleukin 6
dc.subjectiodoacetic acid
dc.subjectisoflurane
dc.subjectmonosodium iodoacetate
dc.subjectproteoglycan
dc.subjectsodium chloride
dc.subjectunclassified drug
dc.subjectupper zone of growth plate and cartilage matrix associated protein
dc.subjectvitamin K group
dc.subjectaggrecanase
dc.subjectcytokine
dc.subjectiodoacetic acid
dc.subjectproteinase
dc.subjectrecombinant protein
dc.subjectsignal peptide
dc.subjectUcma protein, human
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcartilage degeneration
dc.subjectcartilage matrix
dc.subjectchondroprotection
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectdrug mechanism
dc.subjectepiphysis plate
dc.subjecthistopathology
dc.subjectin vivo study
dc.subjectmale
dc.subjectmedial tibial plateau
dc.subjectmicroscopy
dc.subjectmolecular biology
dc.subjectnonhuman
dc.subjectosteoarthritis
dc.subjectoxidative stress
dc.subjectpathophysiology
dc.subjectpriority journal
dc.subjectprotein function
dc.subjectrat
dc.subjecttherapy effect
dc.subjectanimal
dc.subjectarticular cartilage
dc.subjectdrug effect
dc.subjectepiphysis plate
dc.subjectexperimental arthritis
dc.subjectgrowth, development and aging
dc.subjecthuman
dc.subjectimmunology
dc.subjectintraarticular drug administration
dc.subjectmetabolism
dc.subjectosteoarthritis
dc.subjectpathology
dc.subjectsignal transduction
dc.subjectAnimals
dc.subjectArthritis, Experimental
dc.subjectCartilage, Articular
dc.subjectCytokines
dc.subjectEndopeptidases
dc.subjectGrowth Plate
dc.subjectHumans
dc.subjectInjections, Intra-Articular
dc.subjectIntercellular Signaling Peptides and Proteins
dc.subjectIodoacetates
dc.subjectMale
dc.subjectOsteoarthritis
dc.subjectRats
dc.subjectRecombinant Proteins
dc.subjectSignal Transduction
dc.titleIn vivo protective effects of upper zone of growth plate and cartilage matrix associated protein against cartilage degeneration in a monosodium iodoacetate induced osteoarthritis model
dc.typeArticle

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